Gastroenterology Research and Practice / 2016 / Article / Tab 2

Review Article

The C825T Polymorphism of the G-Protein β3 Gene as a Risk Factor for Functional Dyspepsia: A Meta-Analysis

Table 2

Meta-analysis of the association between GNB3 gene C825T polymorphism and functional dyspepsia risk.

ComparisonsOR (95% CI) valueEgger’s test

CC versus TT
 Overall1.15 (0.93–1.44)0.2000.015
 Asia1.12 (0.87–1.43)0.3718%0.049
 America1.34 (0.74–2.42)0.3400.291
 Rome II1.40 (0.98–1.98)0.0600.147
 Rome III1.02 (0.77–1.35)0.8727%0.101
 PCR-RFLP1.55 (1.07–2.24)0.0200.320
 HWE1.06 (0.84–1.35)0.6300.033
 IBS1.16 (0.92–1.46)0.211%0.031
 NOS Score1.12 (0.87–1.43)0.3815%0.015
CC + CT versus TT
 Overall1.16 (0.97–1.39)0.1112%0.057
 Asia1.14 (0.94–1.39)0.1919%0.304
 America1.40 (0.80–2.44)0.2446%0.097
 Rome II1.32 (0.98–1.77)0.0700.126
 Rome III1.08 (0.86–1.35)0.5329%0.475
 PCR-RFLP1.33 (1.00–1.77)0.0519%0.171
 HWE1.08 (0.88–1.32)0.4400.180
 IBS1.17 (0.97–1.41)0.1019%0.052
 NOS Score1.15 (0.94–1.41)0.1731%0.103
CT + TT versus CC
 Overall1.01 (0.77–1.31)0.9659%0.818
 Asia1.00 (0.82–1.23)0.9742%0.078
 America0.67 (0.30–1.50)0.3380%0.215
 Rome II0.99 (0.66–1.49)0.9667%0.098
 Rome III1.00 (0.70–1.43)0.9952%0.157
 PCR-RFLP1.11 (0.69–1.80)0.6759%0.790
 HWE1.02 (0.77–1.34)0.9156%0.603
 IBS0.98 (0.73–1.31)0.8760%0.520
 NOS Score1.02 (0.75–1.38)0.9256%0.807
C versus T
 Overall1.06 (0.96–1.18)0.2625%0.915
 Asia1.06 (0.93–1.20)0.3926%0.082
 America0.97 (0.76–1.25)0.8442%0.384
 Rome II1.14 (0.97–1.33)0.1117%0.094
 Rome III1.01 (0.87–1.16)0.9331%0.190
 PCR-RFLP1.16 (0.97–1.38)0.1043%0.884
 HWE1.04 (0.93–1.17)0.4700.934
 IBS1.05 (0.94–1.17)0.4030%0.730
 NOS Score1.06 (0.94–1.19)0.3724%0.435

HWE, Hardy-Weinberg equilibrium; IBS, irritable bowel syndrome; PCR-RFLP, polymerase chain reaction-restriction fragment-length polymorphism; NOS, Newcastle-Ottawa Scale.

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