The C825T Polymorphism of the G-Protein β3 Gene as a Risk Factor for Functional Dyspepsia: A Meta-Analysis

Table 2

Meta-analysis of the association between GNB3 gene C825T polymorphism and functional dyspepsia risk.

Comparisons	OR (95% CI)	value		Egger’s test
CC versus TT
Overall	1.15 (0.93–1.44)	0.20	0	0.015
Asia	1.12 (0.87–1.43)	0.37	18%	0.049
America	1.34 (0.74–2.42)	0.34	0	0.291
Rome II	1.40 (0.98–1.98)	0.06	0	0.147
Rome III	1.02 (0.77–1.35)	0.87	27%	0.101
PCR-RFLP	1.55 (1.07–2.24)	0.02	0	0.320
HWE	1.06 (0.84–1.35)	0.63	0	0.033
IBS	1.16 (0.92–1.46)	0.21	1%	0.031
NOS Score	1.12 (0.87–1.43)	0.38	15%	0.015
CC + CT versus TT
Overall	1.16 (0.97–1.39)	0.11	12%	0.057
Asia	1.14 (0.94–1.39)	0.19	19%	0.304
America	1.40 (0.80–2.44)	0.24	46%	0.097
Rome II	1.32 (0.98–1.77)	0.07	0	0.126
Rome III	1.08 (0.86–1.35)	0.53	29%	0.475
PCR-RFLP	1.33 (1.00–1.77)	0.05	19%	0.171
HWE	1.08 (0.88–1.32)	0.44	0	0.180
IBS	1.17 (0.97–1.41)	0.10	19%	0.052
NOS Score	1.15 (0.94–1.41)	0.17	31%	0.103
CT + TT versus CC
Overall	1.01 (0.77–1.31)	0.96	59%	0.818
Asia	1.00 (0.82–1.23)	0.97	42%	0.078
America	0.67 (0.30–1.50)	0.33	80%	0.215
Rome II	0.99 (0.66–1.49)	0.96	67%	0.098
Rome III	1.00 (0.70–1.43)	0.99	52%	0.157
PCR-RFLP	1.11 (0.69–1.80)	0.67	59%	0.790
HWE	1.02 (0.77–1.34)	0.91	56%	0.603
IBS	0.98 (0.73–1.31)	0.87	60%	0.520
NOS Score	1.02 (0.75–1.38)	0.92	56%	0.807
C versus T
Overall	1.06 (0.96–1.18)	0.26	25%	0.915
Asia	1.06 (0.93–1.20)	0.39	26%	0.082
America	0.97 (0.76–1.25)	0.84	42%	0.384
Rome II	1.14 (0.97–1.33)	0.11	17%	0.094
Rome III	1.01 (0.87–1.16)	0.93	31%	0.190
PCR-RFLP	1.16 (0.97–1.38)	0.10	43%	0.884
HWE	1.04 (0.93–1.17)	0.47	0	0.934
IBS	1.05 (0.94–1.17)	0.40	30%	0.730
NOS Score	1.06 (0.94–1.19)	0.37	24%	0.435

HWE, Hardy-Weinberg equilibrium; IBS, irritable bowel syndrome; PCR-RFLP, polymerase chain reaction-restriction fragment-length polymorphism; NOS, Newcastle-Ottawa Scale.