Clinicopathologic Significance of Extranodal Tumor Extension in Colorectal Adenocarcinoma with Regional Lymph Node Metastasis

Table 2

Correlations between ENTE and clinicopathologic factors in colorectal adenocarcinoma with regional lymph node metastasis ().

Factors		ENTE		value
		Negative (%)	Positive (%)
		()	()
Age (year)				0.476^†
Mean (±SD)	230	62.66 (±10.30)	63.43 (±12.82)
Gender				0.857^‡
Male	137	72 (52.6%)	32 (47.4%)
Female	93	50 (53.8%)	43 (46.2%)
Tumor size				0.477^†
Mean (±SD)	230	5.13 (±2.06)	5.33 (±2.12)
Gross type				0.026^‡
UI	127	59 (46.5%)	68 (53.5%)
UF & P	103	63 (61.2%)	40 (38.8%)
Location				0.275^‡
Colon	134	67 (50.0%)	67 (50.0%)
Rectum	96	55 (57.3%)	41 (42.7%)
Histologic grade				0.012^‡
Low grade	101	63 (62.4%)	38 (37.6%)
High grade	129	59 (45.7%)	70 (54.3%)
Tumor budding				0.003^‡
Low grade	111	70 (63.1%)	41 (36.9%)
High grade	119	52 (43.7%)	67 (56.3%)
Vascular invasion				<0.001^‡
Absent	158	96 (60.8%)	62 (39.2%)
Present	72	26 (36.1%)	46 (63.9%)
Perineural invasion				0.015^‡
Absent	69	45 (65.2%)	24 (34.8%)
Present	161	77 (47.8%)	84 (52.2%)
Tumor deposit				<0.001^‡
Absent	158	101 (63.9%)	57 (36.1%)
Present	72	21 (29.2%)	51 (70.8%)
MLN/TLN				<0.001^†
Mean ratio (%)	230	15.30 (±14.43)	31.81 (±25.46)
T stage				0.211^‡
T1	2	1 (50.0%)	1 (50.0%)
T2	15	11 (73.3%)	4 (26.7%)
T3	148	81 (54.7%)	67 (45.3%)
T4	65	29 (44.6%)	36 (55.4%)
N stage				<0.001^‡
N1	103	75 (72.8%)	28 (27.2%)
N2	127	47 (37.0%)	80 (63.0%)
Distant metastasis				0.741^‡
Absent	204	109 (53.4%)	95 (46.6%)
Present	26	13 (50.0%)	13 (50.0%)

SD: standard deviation; ^†Mann-Whitney test; ^‡chi-square test; UI: ulceroinfiltrative; UF: ulcerofungating; P: polypoid; MLN/TLN: metastatic lymph nodes/total lymph nodes.