Gastroenterology Research and Practice / 2016 / Article / Tab 1 / Review Article
The Comparative Efficacy and Safety of Entecavir and Lamivudine in Patients with HBV-Associated Acute-on-Chronic Liver Failure: A Systematic Review and Meta-Analysis Table 1 Baseline characteristics of the included studies.
Study Region Study design Number of patients HBV DNA log 10 copies/mL HBeAg-positive PTA (%) or INR (means ± SD) TBIL (means ± SD) (%) ALB (means ± SD) (%) ALT (means ± SD) (%)
Treatment duration (months) ETV LAM ETV LAM ETV LAM ETV LAM ETV LAM ETV LAM ETV LAM
Hu et al., 2010 [25 ] China cohort 90 90 8.2 ± 1 8.2 ± 1 NA NA NA NA NA NA NA NA NA NA 6
Gao et al., 2015 [26 ] China cohort 46 66 NA NA NA NA NA NA NA NA NA NA NA NA 24
Cui et al., 2010 [22 ] China cohort 33 34 5.9 ± 1.5 5.9 ± 1.5 10 13 2.27 ± 0.55 2.61 ± 1.03 20.10 ± 11.24 19.91 ± 8.56 33.36 ± 4.43 31.64 ± 5.32 364 (47–2861) 226.5 (22–2314) 3
Chen et al., 2012 [27 ] China cohort 42 30 7.04 ± 1.6 7.25 ± 0.89 NA NA 34.88 ± 12.27 32.18 ± 11.44 326.29 ± 201.35 332.65 ± 182.65 31.45 ± 5.79 29.59 ± 5.63 324.19 ± 310.04 287.61 ± 261.50 3
Lai et al., 2013 [28 ] China cohort 93 89 NA NA NA NA NA NA NA NA NA NA Na NA 3
Zhang et al., 2014 [21 ] China cohort 65 54 7 ± 1.4 7.2 ± 1.6 21 23 24.7 ± 6.0 25.1 ± 5.7 331.6 ± 74.8 320.1 ± 82.4 28.7 ± 6.9 29.4 ± 5.3 352.5 ± 77.2 345.2 ± 89.5 13
Wen et al., 2010 [19 ] China RCT 46 47 NA NA NA NA 29.8 ± 8.5 30.6 ± 9.1 375.2 ± 200.3 389.4 ± 198.1 31.4 ± 4.6 32.7 ± 3.9 402.5 ± 292.7 395.8 ± 297.4 12
Cai and Shi, 2011 [29 ] China RCT 38 34 NA NA NA NA 34.6 ± 8.1 34.8 ± 9.6 256.5 ± 137.4 257.6 ± 135.9 31.4 ± 4.6 32.8 ± 4.5 395.4 ± 235.3 387.1 ± 245.4 12 He, 2013 [30 ] China RCT 57 57 6.2 ± 2.1 6.1 ± 1.9 NA NA 30 ± 8 30 ± 8 339 ± 135 342 ± 148 31 ± 6 31 ± 6 399 ± 245 404 ± 237 6 Yuan, 2015 [31 ] China RCT 149 148 NA NA NA NA 33.89 ± 7.78 33.96 ± 7.80 260.41 ± 140.11 260.38 ± 140.10 31.88 ± 6.11 31.89 ± 6.10 396.51 ± 240.12 397.00 ± 240.22 12
ETV: entecavir; LAM: lamivudine; NA: not available; PTA: prothrombin activity; INR: international standard ratio; TBIL: total bilirubin; ALB: albumin; ALT: alanine aminotransferase; RCT: randomized controlled studies.