Research Article
Correlation between Histological Activity and Endoscopic, Clinical, and Serologic Activities in Patients with Ulcerative Colitis
Table 1
Geboes scores for assessing ulcerative colitis histological activity.
| | Grade 0: structural (architectural) changes |
| | Subgrades | | | 0.0 | No abnormality | | 0.1 | Mild abnormality | | 0.2 | Mild or moderate diffuse or multifocal abnormalities | | 0.3 | Severe diffuse or multifocal abnormalities |
| | Grade 1: chronic inflammatory infiltrate |
| | Subgrades | | | 1.0 | No increase | | 1.1 | Mild but unequivocal increase | | 1.2 | Moderate increase | | 1.3 | Marked increase |
| | Grade 2: lamina propria neutrophils and eosinophils |
| | 2A: eosinophils | | | 2A.0 | No increase | | 2A.1 | Mild but unequivocal increase | | 2A.2 | Moderate increase | | 2A.3 | Marked increase | | 2B: neutrophils | | | 2B.0 | None | | 2B.1 | Mild but unequivocal increase | | 2B.2 | Moderate increase | | 2B.3 | Marked increase |
| | Grade 3: neutrophils in epithelium |
| | 3.0 | None | | 3.1 | <5% crypts involved | | 3.2 | <50% crypts involved | | 3.3 | >50% crypts involved |
| | Grade 4: crypt destruction |
| | 4.0 | None | | 4.1 | Probable-local excess of neutrophils in part of the crypt | | 4.2 | Probable-marked attenuation | | 4.3 | Unequivocal crypt destruction |
| | Grade 5: erosion or ulceration |
| | 5.0 | No erosion, ulceration, or granulation tissue | | 5.1 | Recovering epithelium + adjacent inflammation | | 5.2 | Probable erosion, focally stripped | | 5.3 | Unequivocal erosion | | 5.4 | Ulcer or granulation tissue |
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