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Gastroenterology Research and Practice
Volume 2016 (2016), Article ID 6134187, 6 pages
Research Article

Bowel Perforation in Premature Infants with Necrotizing Enterocolitis: Risk Factors and Outcomes

1Department of Neonatology, Children’s Hospital of Soochow University, Suzhou 215003, China
2Department of Infectious Disease, Children’s Hospital of Soochow University, Suzhou 215003, China

Received 30 January 2016; Revised 18 April 2016; Accepted 17 May 2016

Academic Editor: Jean-Francois Beaulieu

Copyright © 2016 Lingling Yu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We aim to determine risk factors and clinical outcomes for bowel perforation in premature infants with NEC. We analyzed clinical data of 57 cases of premature infants with NEC at our NICU between January 2010 and December 2012. Based on the presence of bowel perforation, we divided these infants into two groups: perforated NEC group () and nonperforated NEC group (). We compared general information, clinical characteristics, and laboratory findings between groups. The perforated NEC group, compared to the nonperforated NEC group, had significantly lesser gestational age, lower birth weight, higher prevalence of apnea, mechanical ventilation, sepsis and shock, lower blood pH, higher levels of blood glucose, abnormal WBC count and thrombocytopenia, and elevated CRP (all ). Moreover, the perforated NEC group had significantly longer durations of fasting and TPN usage, higher incidences of EUGR and cholestasis, longer duration of antibiotics, higher frequency of advanced antibiotics use, and poorer prognosis than the nonperforated NEC group (all ). Bowel perforation in premature infants with NEC was associated with multiple risk factors. Early identification of some of these risk factors in premature infants with NEC may help implement early intervention to reduce the incidence of bowel perforation and thereby improve the prognosis.