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Gastroenterology Research and Practice
Volume 2016, Article ID 6587825, 7 pages
http://dx.doi.org/10.1155/2016/6587825
Research Article

Snapshot on a Pilot Metagenomic Study for the Appraisal of Gut Microbial Diversity in Mice, Cat, and Man

1Université Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019, UMR 8204, Centre d’Infection et d’Immunité de Lille, 59000 Lille, France
2Genoscreen, Service of Research, Development and Innovation in Health and Environment, 1 rue du Pr Calmette, BP 245, 59019 Lille, France

Received 25 January 2016; Revised 8 March 2016; Accepted 31 March 2016

Academic Editor: Helieh Oz

Copyright © 2016 Coline Plé et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Gut microbiota plays a key role in the maintenance of homeostasis and host physiology, comprising development, metabolism, and immunity. Profiling the composition and the gastrointestinal microbiome with a reliable methodology is of substantial interest to yield new insights into the pathogenesis of many diseases as well as defining new prophylactic and therapeutic interventions. Here, we briefly present our methodology applied to fecal samples from mice and then further extended to the samples from a cat and a single human subject at 4 different time points as examples to illustrate the methodological strengths. Both interindividual and time-related variations are demonstrated and discussed.