NK Cell Subtypes as Regulators of Autoimmune Liver Disease

Table 1

Roles of NK cell in the pathogenesis of autoimmune liver diseases.

Disease	NK cell characteristics	Roles of NK cell in the pathogenesis of disease	Reference
PBC	CD56/CD16; CX3CR1^+; CXCR3^+	(1) Elevated cytotoxic activity, perforin expression, and levels of plasma IL-8; (2) Increased TRAIL expression as an apoptotic inducer in portal tract damage; (3) With TLR4 ligand-stimulated NK cells	[45–49, 53, 54]
AIH	CD16^+CD56^+; CD69^+, CCR5^+; CXCR6^+	(1) Migration in response to the chemotactic stimuli; (2) KIR gene KIR2DS1 in AIH genesis with high affinity HLA-C2 ligands	[39, 57]
PSC	CD16^+CD56^+	(1) Decreased cytolytic activity; (2) NKG2D associated with development of CCA	[58–61]