Corticotropin-Releasing Factor and Toll-Like Receptor Gene Expression Is Associated with Low-Grade Inflammation in Irritable Bowel Syndrome Patients with Depression

Figure 3

TLR2 and TLR4 mRNA expressions in DP-IBS, NDP-IBS, and the control group (0.013 ± 0.002, 0.009 ± 0.003, and 0.006 ± 0.002, resp., , ; , , and , resp., , ). The TLR2 mRNA levels in DP-IBS and NDP-IBS patients were significantly higher than those in the control group, and those in DP-IBS patients were significantly higher than those in NDP-IBS patients (). TLR4 mRNA levels in DP-IBS and NDP-IBS patients were significantly higher than those in the control group, and those in DP-IBS patients were significantly higher than those of NDP-IBS patients ().