Gastroenterology Research and Practice / 2016 / Article / Tab 1

Research Article

Synergistic Effects of Simvastatin and Irinotecan against Colon Cancer Cells with or without Irinotecan Resistance

Table 1

Drug concentrations of simvastatin and irinotecan at various molar ratio based on IC50 value of each drug in HT-29 cells and irinotecan-resistant HT-29 cells.

Molar ratioHT-29Irinotecan-resistant HT-29
Simvastatin (μM)Irinotecan (μM)Simvastatin (μM)Irinotecan (μM)

128.8515.62555.549
257.731.25111.098
4115.462.5221.9195.93

0.980.980.980.99

IC50115.4 ± 0.14 μM62.5 ± 0.18 μM221.9 ± 0.22 μM195.9 ± 0.16 μM