Synergistic Effects of Simvastatin and Irinotecan against Colon Cancer Cells with or without Irinotecan Resistance

Table 1

Drug concentrations of simvastatin and irinotecan at various molar ratio based on IC₅₀ value of each drug in HT-29 cells and irinotecan-resistant HT-29 cells.

Molar ratio	HT-29		Irinotecan-resistant HT-29
	Simvastatin (μM)	Irinotecan (μM)	Simvastatin (μM)	Irinotecan (μM)
1	28.85	15.625	55.5	49
2	57.7	31.25	111.0	98
4	115.4	62.5	221.9	195.93
	0.98	0.98	0.98	0.99
IC50	115.4 ± 0.14 μM	62.5 ± 0.18 μM	221.9 ± 0.22 μM	195.9 ± 0.16 μM