Treatment with Antiangiogenic Drugs in Multiple Lines in Patients with Metastatic Colorectal Cancer: Meta-Analysis of Randomized Trials

Table 1

Overview of studies included in meta-analysis.

Study	First author/year	Investigational treatment	Control treatment	Primary endpoint	Number of patients (ITT); (active/control)
TML	Bennouna 2012 [9]	Chemotherapy (oxaliplatin or irinotecan based); plus bevacizumab	Chemotherapy (oxaliplatin or irinotecan based) alone	OS	819 (409/410)
CORRECT	Grothey 2013 [14]	Regorafenib	Placebo	OS	760 (505/255)
BEBYP	Masi 2013 [10]	Chemotherapy (FOLFIRI, mFOLFOX); plus bevacizumab	Chemotherapy (FOLFIRI, mFOLFOX) alone	PFS	184 (92/92)
VELOUR subgroup	Allegra 2012 [13]	FOLFIRI plus aflibercept	FOLFIRI	OS	373 (186/187)
AGITG subgroup	Siu 2013 [16]	Cetuximab plus brivanib	Cetuximab	OS	310 (152/158)
FOSCO	Hoehler 2013 [17]	FOLFOX/FOLFIRI plus sorafenib	FOLFOX/FOLFIRI plus placebo	PFS	69 (32/37)
RAISE	Tabernero 2015 [18]	FOLFIRI plus ramucirumab	FOLFIRI plus placebo	PFS	1072 (536/536)
CONCUR	Li 2015 [15]	Regorafenib	Placebo	OS	81