Gastroenterology Research and Practice / 2016 / Article / Tab 2

Review Article

Colon Capsule Endoscopy: Review and Perspectives

Table 2

PillCam COLON 2 in colon polyp and cancer detection.

Lead author//year/referenceResults and comments

Akyuz/28/2016/[3]Only 28 of 62 subjects in this study focusing on prep had tandem colonoscopy. 6/28 subjects had polyps in 5–10 mm range. Sensitivity, specificity, PPV, and NPV were 100%, 92%, 93%, 100%

Morgan/50/2016/[4]Of the 50 patients who had tandem capsule and OC 30% and 14% had polyps ≥6 and 10 mm, respectively. For lesions ≥10 mm on OC, capsule sensitivity was 100% and specificity 100%. For polyps ≥6 mm, capsule sensitivity was 93% and specificity 80.0%. The excretion rate was 65%–61% of studies considered adequate cleansing

Hollerhan/62/2014/[5]62 subjects with (+) FIT had tandem capsule/colonoscopy. Sensitivity/specificity for polyps >6 and 10 mm, respectively, was 95/65% and 89/96%, respectively. 92% had adequate cleaning with 73% excretion rate

Hagel/24/2014/[6]Sensitivity/specificity for polyps 6 mm and 10 mm was 72/91 and 75/100%, respectively. Adequate cleansing 90%. Excretion rate 71%. Extracolonic GI pathology >50%

Rex/884/2013/[7]Largest series. Sensitivity/specificity for polyps 6 and 10 mm was 88/82 and 92/95%, respectively. AC 80%. ER 91%

Spada/117/2015/[8]8 European centers: 109 subjects analyzed. Sensitivity/specificity for polyps 6 and 10 mm was 84/64 and 88/95%, respectively. AC 85%. ER 81%

Eliakim/104/2009/[9] Initial validating series for CCE-2. Data from 98 subjects. Sensitivity/specificity for polyps 6 and 10 mm was 89/76 and 88/89%, respectively. AC 78%. ER 81%

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