Functional Bowel Disorders Are Associated with a Central Immune Activation
Table 4
Predictors of IBS and IBS-SSS. The covariates in the logistic and linear regression analyses were group, BDI-II, and IL-10 and TNF in serum and CSF. The results are given as OR (95% CI) and value for the logistic regression analyses and as B (95% CI) and value and partial correlation for the linear regression analyses.
Dependent variables (number of subjects)
Independent variables
Group
BDI-II
TNF
IL-10
B (95% CI) OR (95% CI)
value
B (95% CI) OR (95% CI)
value
Partial corr.
B (95% CI) OR (95% CI)
value
Partial corr.
B (95% CI) OR (95% CI)
value
Partial corr.
TNF serum
IL-10 serum
IBS
OR: 0.72 (0.1; 3.8)
0.717
OR: 1.07 (1.01;1.12)
0.013
OR: 1.06 (0.92; 1.22)
0.428
OR: 1.04 (0.77; 1.41)
0.807
IBS-SSS (65)
B: 30 (− 45; 106)
0.418
B: 2.3 (0.1; 4.5)
0.042
0.260
B: 1.8 (−4.1; 7.6)
0.543
0.079
B: −4.1 (−18.2; 9.9)
0.561
−0.075
TNF-CSF
IL-10 CSF
IBS (62)
OR: 0.63 (0.1; 3.7)
0.609
OR: 1.07 (1.00;1.13)
0.023
OR: 1.25 (0.63; 2.47)
0.528
OR: 0.13 (0.02; 0.92)
0.04
IBS-SSS (61)
B: 33 (−39, 107)
0.360
B: 1.9 (−0.2; 4.1)
0.080
0.232
B: 38 (10; 67)
0.009
0.341
B: −88 (−163, −13)
0.023
−0.299
BDI-II: Beck Depression Inventory-II; IL-10 serum: interleukin 10 in the serum; TNF serum: tumor necrosis factor in serum; IL-10-CSF: interleukin 10 in the cerebrospinal fluid; TNF-CSF: tumor necrosis factor in the cerebrospinal fluid.
