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Gastroenterology Research and Practice
Volume 2017, Article ID 2195361, 11 pages
Review Article

Colorectal Cancer Blood-Based Biomarkers

Department of Molecular Genetics, Institute of Pathology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia

Correspondence should be addressed to Nina Hauptman;

Received 14 April 2017; Revised 16 July 2017; Accepted 13 September 2017; Published 25 September 2017

Academic Editor: Wenhao Weng

Copyright © 2017 Nina Hauptman and Damjan Glavač. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Mortality and morbidity associated with colorectal cancer (CRC) are increasing globally, partly due to lack of early detection of the disease. The screening is usually performed with colonoscopy, which is invasive and unpleasant, discouraging participation in the screening. As a source of noninvasive and easily accessible biomarkers, liquid biopsies are emerging. Blood-based biomarkers have the potential as diagnostic and prognostic tool in CRC. Early stage detection of CRC with high sensitivity and specificity would likely lead to higher participation in the screening test. It would also improve the prognosis of the disease and improve the recurrence risk. In this review, we summarize the potential biomarkers for early detection and monitoring of CRC.