Fibroblast Growth Factor 21 Deficiency Attenuates Experimental Colitis-Induced Adipose Tissue Lipolysis

Figure 5

IL-6 mediates the prolipolysis function of FGF21. Mice were fed as described in the Materials and Methods. (a) Serum IL-6 levels. (b) Linear correlation of the body weight change and serum IL-6 levels. (c) 3T3-L1 adipocytes were pretreated with or without IL-6 for 18 h, followed by treatment with rhFGF21 for 2 h. Median glycerol were determined as described in Materials and Methods.

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