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Gastroenterology Research and Practice
Volume 2017, Article ID 3458739, 8 pages
https://doi.org/10.1155/2017/3458739
Research Article

Role of 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in the Diagnosis of Newly Found Suspected Malignant Solitary Pulmonary Lesions in Patients Who Have Received Curative Treatment for Colorectal Cancer

Xiaozhou Yu,1,2,3 Xiuyu Song,1,2,3 Lei Zhu,1,2,3 Wei Chen,1,2,3 Dong Dai,1,2,3 Xiaofeng Li,1,2,3 and Wengui Xu1,2,3

1Department of Molecular Imaging and Nuclear Medicine, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
2National Clinical Research Center for Cancer, Tianjin, China
3Key Laboratory of Cancer Prevention and Therapy, Tianjin, China

Correspondence should be addressed to Wengui Xu; moc.qq@92174404

Received 9 January 2017; Revised 28 February 2017; Accepted 9 March 2017; Published 12 April 2017

Academic Editor: Nicola Silvestris

Copyright © 2017 Xiaozhou Yu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Positron emission tomography/computed tomography (PET/CT) is recommended for colorectal cancer (CRC) patients with suspected malignant pulmonary lesions. This study aims to systematically discuss the 18F-FDG-PET/CT diagnosis of solitary pulmonary lesions that are strongly suspected to be malignant in CRC patients who have previously undergone curative therapy. Methods. This retrospective study involved 49 consecutive CRC patients who had previously undergone curative therapy and then underwent PET/CT for the investigation of solitary pulmonary lesions that were strongly suspected to be malignant. Results. Pathological examination confirmed the presence of pulmonary metastases (29 patients, 59.2%), primary lung cancer (15 patients, 30.6%), and benign pulmonary disease (5 patients, 10.2%). Small lung lesions, advanced pathological stage, adjuvant chemotherapy after CRC surgery, solitary pulmonary lesions with lower border irregularity, higher carcinoembryonic antigen level, and the lack of concomitant mediastinal lymph node metastasis were more likely to be associated with pulmonary metastasis than with primary lung cancer. None of these factors was independently significant in the multivariate analysis. Conclusion. Clinicopathological characteristics help to differentiate metastasis and primary lung cancer to some extent during the diagnosis of solitary pulmonary lesions suspected to be malignant in this group of patients. This may provide valuable information to clinicians.