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Gastroenterology Research and Practice
Volume 2017, Article ID 3689827, 5 pages
https://doi.org/10.1155/2017/3689827
Research Article

Serum Alanine Aminotransferase Levels within Normal Range Have Different Associations with Augmentation Index and Other Cardiometabolic Risk Factors in Nondrinkers and Drinkers: A Chinese Community-Based Analysis

1Department of Geriatric Cardiology, Chinese People’s Liberation Army General Hospital, Beijing 100853, China
2Department of Cardiology and Hainan Branch, Chinese People’s Liberation Army General Hospital, Beijing 100853, China
3Department of Nephrology and Hainan Branch, Chinese People’s Liberation Army General Hospital, Beijing 100853, China

Correspondence should be addressed to Leiming Luo; moc.anis@miell and Ping Ye; moc.621@103ics

Received 26 December 2016; Revised 9 March 2017; Accepted 19 March 2017; Published 9 May 2017

Academic Editor: Kazuhiko Uchiyama

Copyright © 2017 Shihui Fu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. To investigate whether serum alanine aminotransferase (ALT) levels within normal range were associated with augmentation index (AIx) and cardiometabolic risk factors in nondrinkers and drinkers in Chinese community-dwelling population. Methods. There were 4165 participants with serum ALT levels within normal range. Results. Alcohol drinking was observed in 1173 participants (28.2%). In multivariate analysis, serum ALT levels of nondrinkers were independently associated with age, sex, body mass index (BMI), hypertension, diabetes mellitus, diastolic blood pressure, triglyceride, low-density lipoprotein-cholesterol (LDL-c), and AIx, while serum ALT levels of drinkers were independently associated with age, sex, BMI, triglyceride, and LDL-c ( for all). Conclusions. Associations of serum ALT levels within normal range with age, sex, body height and weight, and blood lipid were simultaneously present in participants with and without alcohol drinking, while associations of serum ALT levels within normal range with AIx, blood pressure, and glucose were seen in nondrinkers rather than in drinkers. These findings not only provide the evidence that serum ALT levels, even within the normal range, have different associations with arteriosclerosis and cardiometabolic risk factors in nondrinkers and drinkers but also are helpful in understanding the underlying pathophysiologic mechanisms linking the hepatic function to arteriosclerosis and cardiometabolic risk factors.