Modulation of Colorectal Cancer Risk by Polymorphisms in 51Gln/His, 64Ile/Val, and 148Asp/Glu of APEX Gene; 23Gly/Ala of XPA Gene; and 689Ser/Arg of ERCC4 Gene
Table 8
Analysis of correlation of selected polymorphisms with the state of tumor according to classification of American Joint Committee on Cancer.
51Gln/His polymorphism of APEX gene
Genotype
Patients ()
II° versus I°
III° + IV° versus I°
III° + IV° versus II°
I°
II°
III°
IV°
OR (95% CI)
OR (95% CI)
OR (95% CI)
Gln/Gln
24
21
19
5
1 (ref)
—
1 (ref)
—
1 (ref)
—
Gln/His
57
94
48
7
1.885 (0.963–3.690)
0.062
0.965 (0.491–1.898)
0.920
0.512 (0.261–1.004)
0.049
His/His
19
15
2
0
0.902 (0.369–2.209)
0.823
—
—
—
—
64Ile/Val polymorphism of APEX
Genotype
Patients ()
II° versus I°
III° + IV° versus I°
III° + IV° versus II°
I°
II°
III°
IV°
OR (95% CI)
OR (95% CI)
OR (95% CI)
Ile/Ile
41
32
19
1
1 (ref)
—
1 (ref)
—
1 (ref)
—
Ile/Val
64
51
28
5
1.021 (0.566–1.843)
1.000
1.057 (0.536–2.086)
0.862
1.035 (0.509–2.105)
0.920
Val/Val
33
17
14
2
0.660 (0.313–1.391)
0.273
0.994 (0.446–2.215)
1.000
1.506 (0.623–3.638)
0.362
148Asp/Glu polymorphism of APEX
Genotype
Patients ()
II° versus I°
III° + IV° versus I°
III° + IV° versus II°
I°
II°
III°
IV°
OR (95% CI)
OR (95% CI)
OR (95% CI)
Asp/Asp
29
17
5
0
1 (ref)
—
1 (ref)
—
1 (ref)
—
Asp/Glu
98
133
5
1
2.315 (1.205–4.449)
0.01
—
—
—
—
Glu/Glu
16
5
0
0
0.533 (0.166–1.716)
0.288
—
—
—
—
23Gly/Ala polymorphism of XPA gene
Genotype
Patients ()
II° versus I°
III° + IV° versus I°
III° + IV° versus II°
I°
II°
III°
IV°
OR (95% CI)
OR (95% CI)
OR (95% CI)
Gly/Gly
17
9
5
0
1 (ref)
—
1 (ref)
—
1 (ref)
—
Gly/Ala
87
165
9
2
3.582 (1.533–8.370)
0.002
—
—
—
—
Ala/Ala
11
5
0
0
0.859 (0.227–3.248)
0.823
—
—
—
—
689Ser/Arg polymorphism of ERCC4
Genotype
Patients ()
II° versus I°
III° + IV° versus I°
III° + IV° versus II°
I°
II°
III°
IV°
OR (95% CI)
OR (95% CI)
OR (95% CI)
Ser/Ser
49
31
9
4
1 (ref)
—
1 (ref)
—
1 (ref)
—
Ser/Arg
83
52
16
4
0.990 (0.561–1.747)
1.000
0.908 (0.415–1.986)
0.806
0.795 (0.356–1.776)
0.578
Arg/Arg
32
24
3
2
1.186 (0.592–2.374)
0.632
0.589 (0.192–1.811)
0.351
0.431 (0.137–1.352)
0.143
Values set in italics denote statistical significance.
