Serotonin-Related Gene Variants in Patients with Irritable Bowel Syndrome and Depressive or Anxiety Disorders

Table 2

Frequency of alleles and genotypes in IBS patients without mental disorders and with depressive or anxiety disorders.

Gene	SNP database number (RS)	Functional variant	Alleles and genotypes		Patients without mental disorders; n (frequency)	Patients with depressive disorders; n (frequency)	Patients with anxiety disorders; n (frequency)
SLC6A4	rs4795541	c.-1950_-1949insC	Alleles	L	53 (0.62)	31 (0.77)	27 (0.54)
				S	29 (0.38)	9 (0.23)	23 (0.46)
			Genotypes	L/L	19 (0.46)	11 (0.55)	8 (0.32)
				L/S	15 (0.37)	9 (0.45)	11 (0.44)
				S/S	7 (0.17)	0	6 (0.24)
				HWE
HTR1A	rs6295	c.1019C>G	Alleles	C	35 (0.44)	24 (0.60)	23 (0.46)
				G	45 (0.56)	16 (0.40)	27 (0.54)
			Genotypes	C/C	8 (0.20)	7 (0.35)	7 (0.28)
				C/G	19 (0.48)	10 (0.50)	9 (0.36)
				G/G	13 (0.32)	3 (0.15)	9 (0.36)
				HWE
HTR2A	rs6313	c.102C>T	Alleles	C	47 (0.59)	22 (0.55)	28 (0.56)
				T	33 (0.41)	18 (0.48)	22 (0.44)
			Genotypes	C/C	13 (0.32)	5 (0.25)	9 (0.36)
				C/T	21 (0.53)	12 (0.60)	10 (0.40)
				T/T	6 (0.15)	3 (0.15)	6 (0.24)
				HWE
	rs6311	c.-1438G>A	Alleles	A	47 (0.57)	16 (0.40)	25 (0.50)
				G	35 (0.43)	24 (0.60)	25 (0.50)
			Genotypes	A/A	14 (0.34)	3 (0.15)	8 (0.32)
				A/G	19 (0.46)	10 (0.50)	9 (0.36)
				G/G	8 (0.20)	7 (0.35)	8 (0.32)
				HWE
HTR2C	rs6318	c.68C>G	Alleles	C	9 (0.11)	7 (0.18)	13 (0.26)
				G	73 (0.89)	33 (0.82)	37 (0.74)
			Genotypes	C/C	0	0	1 (0.04)
				C/G	9 (0.22)	7 (0.35)	11 (0.44)
				G/G	32 (0.78)	13 (0.65)	13 (0.52)
				HWE
TPH1	rs1800532	c.218A>C	Alleles	A	36 (0.44)	19 (0.47)	19 (0.38)
				C	46 (0.56)	21 (0.53)	31 (0.62)
			Genotypes	A/A	10 (0.24)	3 (0.15)	5 (0.20)
				A/C	16 (0.39)	13 (0.65)	9 (0.36)
				C/C	15 (0.37)	4 (0.20)	11 (0.44)
				HWE

HWE: Hardy-Weinberg equilibrium test.