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Gastroenterology Research and Practice
Volume 2017 (2017), Article ID 4653250, 7 pages
Research Article

Are the Symptoms of an NSAID-Induced Ulcer Truly Milder Than Those of an Ordinary Ulcer?

1Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo, Japan
2Department of Internal Medicine, Nishinomiya Kyoritsu Neurosurgical Hospital, Hyogo, Japan
3Department of Internal Medicine, Kyoritsu Hospital, Hyogo, Japan
4Department of Internal Medicine, Amagasaki Central Hospital, Hyogo, Japan
5Division of Gastroenterology, Takarazuka Municipal Hospital, Hyogo, Japan

Correspondence should be addressed to Hiroto Miwa

Received 2 May 2017; Accepted 18 July 2017; Published 27 August 2017

Academic Editor: Greger Lindberg

Copyright © 2017 Toshihiko Tomita et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. The percentage of patients with nonsteroidal anti-inflammatory drugs (NSAIDs) and low-dose aspirin- (LDA-) induced ulcers who complain of gastrointestinal symptoms has generally been considered to be low. The aim of this study was to examine and compare the symptoms and quality of life (QOL) at peptic ulcer onset. Methods. This study involved 200 patients who were confirmed by endoscopy to be in the acute stage of gastroduodenal ulcer (A1-H1). Patients completed a self-administered questionnaire (Global Overall Symptom score and SF-8) at ulcer onset, and data were compared between NSAIDs/LDA ulcers and non-NSAIDs/LDA ulcers. Results. The upper gastrointestinal symptoms score was significantly lower for patients using LDA only (20.5 ± 9.4 in the nonusing group, 19.6 ± 8.6 in the NSAIDs-only group, 16.7 ± 11.6 in the LDA-only group, and 18.5 ± 7.2 in the NSAIDs/LDA group, ). The QOL score (physical summary) was significantly lower in the NSAID group (42.1 ± 9.9) than in the nonusing group (47.6 ± 7.6) (). Patients’ characteristics showed no significant differences among the groups, with the exception of age. Conclusion. The severity of upper abdominal symptoms at peptic ulcer onset was similar between NSAID users and nonusers.