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Gastroenterology Research and Practice
Volume 2017, Article ID 6710931, 7 pages
https://doi.org/10.1155/2017/6710931
Research Article

Proximal Sessile Serrated Adenomas Are More Prevalent in Caucasians, and Gastroenterologists Are Better Than Nongastroenterologists at Their Detection

1Department of Gastroenterology and Hepatology, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
2Department of Internal Medicine, Presence Saint Francis Hospital, 355 Ridge Ave, Evanston, IL 60202, USA
3Department of Biostatistics and Quantitative Health Sciences, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA

Correspondence should be addressed to Madhusudhan R. Sanaka; gro.fcc@makanas

Received 21 August 2017; Revised 4 November 2017; Accepted 23 November 2017; Published 18 December 2017

Academic Editor: Robert Odze

Copyright © 2017 Malav P. Parikh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. T. Hetzel, C. S. Huang, J. A. Coukos et al., “Variation in the detection of serrated polyps in an average risk colorectal cancer screening cohort,” The American Journal of Gastroenterology, vol. 105, no. 12, pp. 2656–2664, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. E. R. Fearon and B. Vogelstein, “A genetic model for colorectal tumorigenesis,” Cell, vol. 61, no. 5, pp. 759–767, 1990. View at Publisher · View at Google Scholar · View at Scopus
  3. B. Leggett and V. Whitehall, “Role of the serrated pathway in colorectal cancer pathogenesis,” Gastroenterology, vol. 138, no. 6, pp. 2088–2100, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. M. J. O'Brien, “Hyperplastic and serrated polyps of the colorectum,” Gastroenterology Clinics of North America, vol. 36, no. 4, pp. 947–968, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. E. Torlakovic and D. C. Snover, “Serrated adenomatous polyposis in humans,” Gastroenterology, vol. 110, no. 3, pp. 748–755, 1996. View at Publisher · View at Google Scholar · View at Scopus
  6. C. S. Huang, M. J. O'Brien, S. Yang, and F. A. Farraye, “Hyperplastic polyps, serrated adenomas, and the serrated polyp neoplasia pathway,” The American Journal of Gastroenterology, vol. 99, no. 11, pp. 2242–2255, 2004. View at Publisher · View at Google Scholar · View at Scopus
  7. N. S. Goldstein, “Serrated pathway and APC (conventional)-type colorectal polyps: molecular-morphologic correlations, genetic pathways, and implications for classification,” American Journal of Clinical Pathology, vol. 125, no. 1, pp. 146–153, 2006. View at Publisher · View at Google Scholar
  8. M. A. Arain, M. Sawhney, S. Sheikh et al., “CIMP status of interval colon cancers: another piece to the puzzle,” The American Journal of Gastroenterology, vol. 105, no. 5, pp. 1189–1195, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. K. J. Spring, Z. Z. Zhao, R. Karamatic et al., “High prevalence of sessile serrated adenomas with BRAF mutations: a prospective study of patients undergoing colonoscopy,” Gastroenterology, vol. 131, no. 5, pp. 1400–1407, 2006. View at Publisher · View at Google Scholar · View at Scopus
  10. D. J. Weisenberger, K. D. Siegmund, M. Campan et al., “CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer,” Nature Genetics, vol. 38, no. 7, pp. 787–793, 2006. View at Publisher · View at Google Scholar · View at Scopus
  11. T. Kambara, L. A. Simms, V. L. Whitehall et al., “BRAF mutation is associated with DNA methylation in serrated polyps and cancers of the colorectum,” Gut, vol. 53, no. 8, pp. 1137–1144, 2004. View at Publisher · View at Google Scholar · View at Scopus
  12. D. C. Snover, J. R. Jass, C. Fenoglio-Preiser, and K. P. Batts, “Serrated polyps of the large intestine: a morphologic and molecular review of an evolving concept,” American Journal of Clinical Pathology, vol. 124, no. 3, pp. 380–391, 2005. View at Publisher · View at Google Scholar
  13. T. R. de Wijkerslooth, E. M. Stoop, P. M. Bossuyt et al., “Differences in proximal serrated polyp detection among endoscopists are associated with variability in withdrawal time,” Gastrointestinal Endoscopy, vol. 77, no. 4, pp. 617–623, 2013. View at Publisher · View at Google Scholar · View at Scopus
  14. D. K. Rex, D. J. Ahnen, J. A. Baron et al., “Serrated lesions of the colorectum: review and recommendations from an expert panel,” The American Journal of Gastroenterology, vol. 107, no. 9, pp. 1315–1329, 2012. View at Publisher · View at Google Scholar · View at Scopus
  15. D. Snover, D. J. Ahnen, R. W. Burt, and R. D. Odze, “Serrated polyps of the colon and rectum and serrated (“hyperplastic”) polyposis,” in WHO Classification of Tumours Pathology and Genetics Tumours of the digestive system, F. T. Bozman, F. Carneiro, R. H. Hruban et al., Eds., Springer-Verlag, Berlin, 4th edition, 2010. View at Google Scholar
  16. C. J. Kahi, D. G. Hewett, D. L. Norton, G. J. Eckert, and D. K. Rex, “Prevalence and variable detection of proximal colon serrated polyps during screening colonoscopy,” Clinical Gastroenterology and Hepatology, vol. 9, no. 1, pp. 42–46, 2011. View at Publisher · View at Google Scholar · View at Scopus
  17. K. Abdeljawad, K. C. Vemulapalli, C. J. Kahi, O. W. Cummings, D. C. Snover, and D. K. Rex, “Sessile serrated polyp prevalence determined by a colonoscopist with a high lesion detection rate and an experienced pathologist,” Gastrointestinal Endoscopy, vol. 81, no. 3, pp. 517–524, 2015. View at Publisher · View at Google Scholar · View at Scopus
  18. S. R. Gurudu, R. I. Heigh, G. de Petris et al., “Sessile serrated adenomas: demographic, endoscopic and pathological characteristics,” World Journal of Gastroenterology, vol. 16, no. 27, pp. 3402–3405, 2010. View at Publisher · View at Google Scholar · View at Scopus
  19. M. R. Sanaka, T. Gohel, A. Podugu et al., “Adenoma and sessile serrated polyp detection rates: variation by patient sex and colonic segment but not specialty of the endoscopist,” Diseases of the Colon & Rectum, vol. 57, no. 9, pp. 1113–1119, 2014. View at Publisher · View at Google Scholar · View at Scopus
  20. U.S. Cancer Statistics Working Group, United States Cancer Statistics: 1999–2014 Incidence and Mortality Web-based Report, Department of Health and Human Services, Centers for Disease Control and Prevention, and National Cancer Institute, Atlanta (GA), 2017, http://www.cdc.gov/uscs.
  21. V. Kumbhari, J. Behary, and J. M. Hui, “Prevalence of adenomas and sessile serrated adenomas in Chinese compared with Caucasians,” Journal of Gastroenterology and Hepatology, vol. 28, no. 4, pp. 608–612, 2013. View at Publisher · View at Google Scholar · View at Scopus
  22. C. J. Kahi, X. Li, G. J. Eckert, and D. K. Rex, “High colonoscopic prevalence of proximal colon serrated polyps in average-risk men and women,” Gastrointestinal Endoscopy, vol. 75, no. 3, pp. 515–520, 2012. View at Publisher · View at Google Scholar · View at Scopus
  23. US Census Bureau, 2015, May 2017, https://www.census.gov/quickfacts/fact/table/US/PST045216.
  24. M. P. Parikh, V. Wadhwa, Y. Jobanputra, K. Naha, P. N. Thota, and M. R. Sanaka, “Tu1024 high-risk adenoma detection rate: varies by race and fellow participation but not by timing of colonoscopy,” Gastrointestinal Endoscopy, vol. 85, no. 5, article AB538, 2017. View at Publisher · View at Google Scholar
  25. K. Wallace, H. M. Brandt, J. D. Bearden et al., “Race and prevalence of large bowel polyps among the low-income and uninsured in South Carolina,” Digestive Diseases and Sciences, vol. 61, no. 1, pp. 265–272, 2016. View at Publisher · View at Google Scholar · View at Scopus
  26. S. J. Pietrak, M. Kang, D. Patel, T. Colangelo, and A. S. Ahmad, “Su1668 risk factors for the development of sessile serrated adenomas in a predominantly African-American, female, obese inner city population,” Gastrointestinal Endoscopy, vol. 85, no. 5, article AB388, 2017. View at Publisher · View at Google Scholar
  27. J. M. Carethers, B. Murali, B. Yang et al., “Influence of race on microsatellite instability and CD8+ T cell infiltration in colon cancer,” PLoS One, vol. 9, no. 6, article e100461, 2014. View at Publisher · View at Google Scholar · View at Scopus
  28. D. A. Corley, C. D. Jensen, A. R. Marks et al., “Variation of adenoma prevalence by age, sex, race, and colon location in a large population: implications for screening and quality programs,” Clinical Gastroenterology and Hepatology, vol. 11, no. 2, pp. 172–180, 2013. View at Publisher · View at Google Scholar · View at Scopus
  29. J. W. Cordice Jr. and H. Johnson Jr., “Anatomic distribution of colonic cancers in middle-class black Americans,” Journal of the National Medical Association, vol. 83, no. 8, pp. 730–732, 1991. View at Google Scholar
  30. K. C. Chu, R. E. Tarone, W. H. Chow, and G. A. Alexander, “Colorectal cancer trends by race and anatomic subsites, 1975–1991,” Archives of Family Medicine, vol. 4, no. 10, pp. 849–856, 1995. View at Publisher · View at Google Scholar
  31. D. A. Lieberman, J. L. Williams, J. L. Holub et al., “Race, ethnicity, and sex affect risk for polyps greater than 9 mm in average-risk individuals,” Gastroenterology, vol. 147, no. 2, pp. 351–358, 2014. View at Publisher · View at Google Scholar · View at Scopus
  32. D. K. Rex, A. M. Khan, P. Shah, J. Newton, and O. W. Cummings, “Screening colonoscopy in asymptomatic average-risk African Americans,” Gastrointestinal Endoscopy, vol. 51, no. 5, pp. 524–527, 2000. View at Publisher · View at Google Scholar · View at Scopus
  33. M. R. Sanaka, F. Deepinder, P. N. Thota, R. Lopez, and C. A. Burke, “Adenomas are detected more often in morning than in afternoon colonoscopy,” The American Journal of Gastroenterology, vol. 104, no. 7, pp. 1659–1664, 2009. View at Publisher · View at Google Scholar · View at Scopus
  34. M. Y. Chan, H. Cohen, and B. M. R. Spiegel, “Fewer polyps detected by colonoscopy as the day progresses at a veteran’s administration teaching hospital,” Clinical Gastroenterology and Hepatology, vol. 7, no. 11, pp. 1217–1223, 2009. View at Publisher · View at Google Scholar · View at Scopus
  35. S. Diamond, K. M. Hoda, J. L. Holub, D. A. Lieberman, and G. M. Eisen, “392 does the time of day predict the yield for significant neoplasia on screening colonoscopy?” Gastroenterology, vol. 138, no. 5, pp. S-57–S-58, 2010. View at Publisher · View at Google Scholar
  36. M. P. Parikh, Y. Jobanputra, K. Naha, V. Wadhwa, P. N. Thota, and M. R. Sanaka, “Mo1130 impact of race, timing of colonoscopy and fellow participation on sessile serrated adenoma detection rate (SSADR),” Gastrointestinal Endoscopy, vol. 85, no. 5, article AB440, 2017. View at Publisher · View at Google Scholar
  37. B. T. Clark, T. Rustagi, and L. Laine, “What level of bowel prep quality requires early repeat colonoscopy: systematic review and meta-analysis of the impact of preparation quality on adenoma detection rate,” The American Journal of Gastroenterology, vol. 109, no. 11, pp. 1714–1723, 2014. View at Publisher · View at Google Scholar · View at Scopus
  38. H. Yark, M. López-Cerón, J. E. East et al., “Endoscopic features of sessile serrated adenomas: validation by international experts using high-resolution white-light endoscopy and narrow-band imaging,” Gastrointestinal Endoscopy, vol. 77, no. 6, pp. 916–924, 2013. View at Publisher · View at Google Scholar · View at Scopus
  39. H.-J. Yang, J. I. Lee, S.-K. Park et al., “External validation of the endoscopic features of sessile serrated adenomas in expert and trainee colonoscopists,” Clinical Endoscopy, vol. 50, no. 3, pp. 279–286, 2017. View at Publisher · View at Google Scholar
  40. J. C. Anderson, L. F. Butterly, C. M. Robinson, M. Goodrich, and J. E. Weiss, “Impact of fair bowel preparation quality on adenoma and serrated polyp detection: data from the New Hampshire colonoscopy registry by using a standardized preparation-quality rating,” Gastrointestinal Endoscopy, vol. 80, no. 3, pp. 463–470, 2014. View at Publisher · View at Google Scholar · View at Scopus
  41. J. N. Rogart, U. D. Siddiqui, P. A. Jamidar, and H. R. Aslanian, “Fellow involvement may increase adenoma detection rates during colonoscopy,” The American Journal of Gastroenterology, vol. 103, no. 11, pp. 2841–2846, 2008. View at Publisher · View at Google Scholar · View at Scopus
  42. A. M. Buchner, M. W. Shahid, M. G. Heckman et al., “Trainee participation is associated with increased small adenoma detection,” Gastrointestinal Endoscopy, vol. 73, no. 6, pp. 1223–1231, 2011. View at Publisher · View at Google Scholar · View at Scopus
  43. E. Qayed, L. Shea, S. Goebel, and R. M. Bostick, “Association of trainee participation with adenoma and polyp detection rates,” World Journal of Gastrointestinal Endoscopy, vol. 9, no. 5, pp. 204–210, 2017. View at Publisher · View at Google Scholar
  44. S. L. Peters, A. G. Hasan, N. B. Jacobson, and G. L. Austin, “Level of fellowship training increases adenoma detection rates,” Clinical Gastroenterology and Hepatology, vol. 8, no. 5, pp. 439–442, 2010. View at Publisher · View at Google Scholar · View at Scopus
  45. C. W. Ko, J. A. Dominitz, P. Green, W. Kreuter, and L. M. Baldwin, “Specialty differences in polyp detection, removal, and biopsy during colonoscopy,” The American Journal of Medicine, vol. 123, no. 6, pp. 528–535, 2010. View at Publisher · View at Google Scholar · View at Scopus
  46. S. D. Wexner, K. A. Forde, G. Sellers et al., “How well can surgeons perform colonoscopy?” Surgical Endoscopy, vol. 12, no. 12, pp. 1410–1414, 1998. View at Publisher · View at Google Scholar
  47. A. Bhangu, D. M. Bowley, R. Horner, E. Baranowski, S. Raman, and S. Karandikar, “Volume and accreditation, but not specialty, affect quality standards in colonoscopy,” The British Journal of Surgery, vol. 99, no. 10, pp. 1436–1444, 2012. View at Publisher · View at Google Scholar · View at Scopus
  48. J. M. Charbel, A. L. Bastawrous, D. Froese et al., “Colon and rectal surgeons: raising the endoscopy bar,” Journal of the American College of Surgeons, vol. 221, no. 4, article e57, 2015. View at Publisher · View at Google Scholar
  49. D. Pace, M. Borgaonkar, B. Evans et al., “Annual colonoscopy volume and maintenance of competency for surgeons,” Surgical Endoscopy, vol. 31, no. 6, pp. 2630–2635, 2017. View at Publisher · View at Google Scholar · View at Scopus
  50. N. Horton, A. Garber, H. Hasson, R. Lopez, and C. A. Burke, “Impact of single- vs. split-dose low-volume bowel preparations on bowel movement kinetics, patient inconvenience, and polyp detection: a prospective trial,” The American Journal of Gastroenterology, vol. 111, no. 9, pp. 1330–1337, 2016. View at Publisher · View at Google Scholar · View at Scopus