Research Article

Gamma-Glutamyl Transpeptidase-to-Platelet Ratio Predicts Significant Liver Fibrosis of Chronic Hepatitis B Patients in China

Table 2

Laboratory parameters and serum markers of different stages.

StageF0F1F2F3F4 value

Age34.5 (29, 42)38.5 (32, 48)44.5 (38.5, 51)39 (32, 47.75)38.5 (31.5, 47.5)0.075
AST25.5 (20.5, 36.25)31.95 (24.75, 85.75)31.15 (24.6, 37.18)39.45 (24.52, 52.5)34.5 (27, 76.9)0.022
ALT34 (22.5, 54.75)47.3 (30.08, 96.08)35.45 (27.78, 50.5)49.5 (23.25, 66.05)32.5 (24.75, 59.5)0.238
γ-GT18.5 (13.75, 42.75)34.5 (22.9, 72.85)34.65 (19.42, 53.83)47 (35.4, 68)46.5 (30.6, 126.05)<0.001
PLT191.5 (155.75, 228.25)185.5 (158.25, 217.5)157.5 (116.25, 182.5)144.5 (104, 184.25)137.5 (107.75, 195)0.001
HBV DNA984 (112.5, 14825000)162500 (819.75, 5130000)806 (364.75, 33475)17800 (877.75, 484500)11750 (834.75, 108375)0.146
GPR0.19 (0.15, 0.29)0.34 (0.25, 0.70)0.47 (0.25, 0.72)0.63 (0.41, 1.27)0.60 (0.30, 1.24)<0.001
APRI0.21 (0.15, 0.35)0.49 (0.31, 1.24)0.49 (0.38, 0.85)0.73 (0.35, 1.60)0.74 (0.44, 1.40)0.003
Fib-40.84 (0.63, 1.14)1.09 (0.90, 1.70)1.63 (1.13, 1.96)1.59 (1.05, 2.48)2.03 (0.95, 3.18)<0.001