Gamma-Glutamyl Transpeptidase-to-Platelet Ratio Predicts Significant Liver Fibrosis of Chronic Hepatitis B Patients in China

Table 5

Diagnostic thresholds and accuracies of serum models for liver fibrosis and cirrhosis.

	Cut-off value	Se (%)	Sp (%)	PPV (%)	NPV (%)
GPR
≥F1	0.26	80	65	88	43
≥F2	0.35	77	64	59	80
≥F3	0.38	76	60	48	86
≥F4	0.72	81	50	28	91
APRI
≥F2	0.5	61	52	49	62
	1.5	20	86	50	62
≥F4	1	27	77	16	87
	2	23	88	25	88
Fib-4
≥F3	1.45	59	69	44	81
	3.25	22	95	63	75

APRI = aspartate transaminase-to-platelet ratio index; AUROC = the area under the receiver operating characteristic curve; CI = confidence interval; Fib-4 = fibrosis index based on the four factors; GPR = gamma-glutamyl transpeptidase-to-platelet ratio index; NPV = negative predictive value; PPV = positive predictive value; Se = sensitivity; Sp = specificity; WHO = World Health Organization.