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Gastroenterology Research and Practice
Volume 2017 (2017), Article ID 7150386, 11 pages
Review Article

Association between HLA-DQ Gene Polymorphisms and HBV-Related Hepatocellular Carcinoma

1Department of Biochemistry and Molecular Biology, Bengbu Medical College, Bengbu 233003, China
2Department of Clinical Laboratory, Bengbu Medical College, Bengbu, Anhui 233030, China
3Department of Microbiology and Immunology, Medical School of Southeast University, Nanjing, Jiangsu 210009, China
4Clinical Testing and Diagnose Experimental Center of Bengbu Medical College, Bengbu, Anhui 233030, China
5Department of Immunology, Bengbu Medical College, Bengbu Anhui 233030, China
6Anhui Key Laboratory of Infection and Immunity, Bengbu Medical College, Bengbu Anhui 233030, China

Correspondence should be addressed to Hongtao Wang

Received 27 March 2017; Revised 23 May 2017; Accepted 8 June 2017; Published 6 July 2017

Academic Editor: Tatsuya Toyokawa

Copyright © 2017 Jingzhu Lv et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-related mortality worldwide. Host gene variants may influence hepatitis B virus- (HBV-) related HCC. Human leukocyte antigens (HLA) play an important role in presenting virus antigens to immune cells that are responsible for the clearance of virus-infected cells and tumor cells. Previous studies have investigated the HLA-DQ (rs2856718 and rs9275572) polymorphisms that may be associated with the development of HBV-related HCC. However, the results are controversial or inconclusive. Hence, we conducted a meta-analysis to derive a more precise estimation of the associations. A total of 6 articles were used to evaluate the effect of the two polymorphisms on the risk of HBV-related HCC. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated. We found that rs2856718 and rs9275572 in HLA-DQ significantly decreased HBV-related HCC in total population, especially in Chinese, but not in Saudi Arabian. Further validation of our results in larger populations and different ethnicities are required.