Association between HLA-DQ Gene Polymorphisms and HBV-Related Hepatocellular Carcinoma
Table 3
Main results of the meta-analysis of the association between HLA-DQ (rs9275572) polymorphisms and the risk of HBV-related HCC.
Comparison
Subgroup
OR (95% CI)
Model
Heterogeneity test
PZ
PE
I2 (%)
PH
HCC versus control
Dominant model (AA + AG versus GG)
Overall
0.49 (0.40–0.61)
F
0
0.416
<0.001
0.391
Chinese
0.46 (0.36–0.57)
F
0
0.825
<0.001
0.168
Saudi Arabian
0.69 (0.43–1.10)
0.120
Recessive model (AA versus AG + GG)
Overall
0.37 (0.24–0.56)
F
0
0.659
<0.001
0.698
Chinese
0.31 (0.19–0.52)
F
0
0.885
<0.001
0.216
Saudi Arabian
0.54 (0.25–1.15)
0.108
Homozygous model (AA versus GG)
Overall
0.29 (0.19–0.45)
F
0
0.537
<0.001
0.652
Chinese
0.25 (0.15–0.41)
F
0
0.842
<0.001
0.208
Saudi Arabian
0.47 (0.27–1.05)
0.065
Heterozygous model (AG versus GG)
Overall
0.56 (0.45–0.69)
F
0
0.525
<0.001
0.491
Chinese
0.52 (0.40–0.66)
F
0
0.939
<0.001
0.097
Saudi Arabian
0.77 (0.47–1.27)
0.311
Allele model (A versus G)
Overall
0.52 (0.44–0.62)
F
0
0.280
<0.001
0.501
Chinese
0.48 (0.40–0.58)
F
0
0.782
<0.001
0.165
Saudi Arabian
0.70 (0.49–1.00)
21.8
0.048
HCC versus CHB
Dominant model (AA + AG versus GG)
Overall
0.75 (0.64–0.88)
F
0
0.832
<0.001
0.674
Chinese
0.74 (0.63–0.88)
F
0
0.700
0.001
0.616
Saudi Arabian
0.79 (0.47–1.32)
0.369
Recessive model (AA versus AG + GG)
Overall
0.61 (0.42–0.87)
F
0
0.885
0.007
0.780
Chinese
0.57 (0.38–0.85)
F
0
0.882
0.006
0.877
Saudi Arabian
0.80 (0.35–1.86)
0.608
Homozygous model (AA versus GG)
Overall
0.55 (0.38–0.80)
F
0
0.934
0.002
0.766
Chinese
0.52 (0.35–0.79)
F
0
0.934
0.002
0.897
Saudi Arabian
0.72 (0.30–1.74)
0.469
Heterozygous model (AG versus GG)
Overall
0.78 (0.66–0.93)
F
0
0.727
0.005
0.651
Chinese
0.78 (0.65–0.93)
F
0
0.566
0.007
0.649
Saudi Arabian
0.81 (0.47–1.39)
0.441
Allele model (A versus G)
Overall
0.76 (0.67–0.87)
F
0
0.916
<0.001
0.750
Chinese
0.75 (0.65–0.87)
F
0
0.869
<0.001
0.529
Saudi Arabian
0.83 (0.57–1.23)
0.362
OR: odds ratio; CI: confidence interval, PH: value of heterogeneity test; PZ: value of Z test; PE: value of Egger’s test; R: random effect model; F: fixed effect model. Because there was only one study with this genotype of rs9275572, the value could not be calculated.
