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Gastroenterology Research and Practice
Volume 2017, Article ID 7213043, 5 pages
Review Article

Four Major Factors Contributing to Intrahepatic Stones

1Department of General Surgery, Huashan Hospital, Fudan University, Shanghai, China
2Department of General Surgery, Jing’an District Center Hospital of Shanghai, Fudan University, Shanghai, China

Correspondence should be addressed to Baojin Ma; moc.621@qwscam

Received 22 August 2016; Revised 30 October 2016; Accepted 13 December 2016; Published 9 January 2017

Academic Editor: Michel Kahaleh

Copyright © 2017 Xi Ran et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Intrahepatic stone is prevalent in Asian countries; though the incidence declines in recent years, the number of patients is still in a large quantity. Because of multiple complications, high recurrence rates, serious systemic damage, and a lack of extremely effective procedure for the management, it is more important to find out the etiology and pathogenesis of intrahepatic stones to prevent the disease from happening and developing rather than curing. A number of factors contribute to the development of the disease, such as cholestasis, infection, and anatomic abnormity of bile duct and bile metabolic defect. The four factors and possible pathogenesis will be discussed in detail in the review.