Hepatitis C Virus and Nonliver Solid Cancers: Is There an Association between HCV and Cancers of the Pancreas, Thyroid, Kidney, Oral Cavity, Breast, Lung, and Gastrointestinal Tract?

Table 8

Cohort studies for association of chronic HCV infection with oral cancer (OC).

Author	Country	Study period	Total number; of subjects	OC (n)/HCV (+); cases (n)	OC (n)/HCV (−); cases (n)	OC	EC	Person-years	Risk (95% CI)
Su et al. [45]	Taiwan	1996–2008		21/5311	147/84796	NA	NA	78,803	HR 1.9 (1.2–3.0)
Amin et al. [28]	Australia	1990–2002	117,547	19/75,834	NA	NA	NA	356,775	SIR; Mouth—1.5 (0.7–3.2); Tongue—1.1 (0.5–2.4); Tonsil—2.1 (1.0–4.8)
Allison et al. [34]	Australia	1993–2007	29,613	Mouth 3/14,892; Lip 3/14,892	NA	Mouth 3; Lip 3	Mouth 0.58; Lip 2.19	213,008	SIR; Mouth—5.1 (1.0–15.0); Lip—1.3 (0.28–4.00)

OC: observed cases; EC: expected cases; CI: confidence interval; SIR: standardized incidence rate; SMR: standardized mortality rate; NA: not available.