Screening Biomarker as an Alternative to Endoscopy for the Detection of Early Gastric Cancer: The Combination of Serum Trefoil Factor Family 3 and Pepsinogen

Figure 2

Receiver operating characteristic (ROC) curves of trefoil factor family 3 (TFF3) to predict early gastric cancer presence in the derivation cohort. (a) ROC curve of serum TFF3 for all (both Helicobacter pylori-positive and Helicobacter pylori-negative) the patients. The sensitivity, specificity, odds ratio, area under the curve, and cutoff value of TFF3 were 0.804, 0.576, 5.60, 0.729, and 6.73, respectively. The positive and negative predictive values of TFF3 were 0.430 and 0.881, respectively. (b) For H. pylori-positive patients, the sensitivity, specificity, odds ratio, and area under the curve were 0.772, 0.576, 4.61, and 0.716, respectively. (c) For H. pylori-negative patients, the sensitivity, specificity, odds ratio, and area under the curve were 0.835, 0.576, 6.86, and 0.740, respectively.

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