Screening Biomarker as an Alternative to Endoscopy for the Detection of Early Gastric Cancer: The Combination of Serum Trefoil Factor Family 3 and Pepsinogen

Figure 4

The Receiver operating characteristic curves of pepsinogen I/II ratio, serum trefoil factor family 3 (TFF3), and TFF3 plus pepsinogen I/II ratio are shown in the validation cohort. The sensitivity, specificity, odds ratio, and area under the curve of pepsinogen test for detection of EGC according to the definition of pepsinogen test were 0.333, 0.933, 7.00, and 0.633, respectively. Using the cutoff value of 6.73 ng/mL for TFF3, those for TFF3 were 0.800, 0.433, 3.06, and 0.651, respectively. Those for the combination of TFF3 and pepsinogen l/ll ratio were 0.900, 0.367, 5.21, and 0.756, respectively. AUC: area under the curve.