Review Article

Efficacy and Safety of Argon Plasma Coagulation for Hemorrhagic Chronic Radiation Proctopathy: A Systematic Review

Table 1

Characteristics of studies included in the systematic review.

First author (year, area)Study designAgeCancer typesNo. of patientsElectric power (W: watt)Argon gas flow rate (L/min)Rate of complicationFrequencies of sessionRate of hemostasisFollow-up (m: month)Loss-up

Higuera (2004, Spain)Retrospective67.8 (58–76)Cervical (1), endometrial (6), >and prostate (3) cancer10601.5–20.0%1.9 (1–4)78.631.8 m (10–45 m)0
Alfadhli (2008, Kuwait)Prospective74.7na1445–501.2–214.3%1.7885.73 m0
Alvaro (2011, Mexico)Prospective59.3 ± 12na14601.635.7%3 ± 192.63 m0
Ben (2004, France)Prospective73.1 (53–86)Prostate (19), anal (4), uterine (3), and rectal (1) cancer2740–500.8–118.5%2.66 (1–7)92.913.6 m (3–31 m)0
Canard (2003, France)Prospective70.7 (58–85)Prostate (23), uterine (4), cervical (1), and squamous-cell anus (1) cancer and uterine (1) sarcoma3042 (30–80)1.5 (0.8–1.2)26.7%69, 2.3 (1–5)95.21–35 m2
Chruscielewska (2013, Poland)Prospective65.5 ± 10.9Cervical (16), endometrial (17), prostate (28), and rectal (1) cancer6225–401.5–2/1–1.558.1%2 (1–3)91.752 weeks0
Chutkan (1997, USA)Prospective72 (64–85)Prostate (10) and uterine (2) cancer12nana0.0%1 (1-2)97.96.6 m (3–13 m)0
Dees (2006, Netherlands)Prospective73.6 (59–89)Prostate (45), urinary bladder (4), and uterine cervix (1) cancer505022.0%3 (1–6)100na2
Fantin (1999, Switzerland)RetrospectivenaProstate (6) and endometrial cancer (1)76030.0%2 (2–4)9024 m (18–24 m)0
Hortelano (2014, Spain)Retrospective70 (56–78)Prostate cancer30501.86.67%376.714.5 m (2–61 m)0
Kaassis (2000, France)Retrospective73.5 (62–80)Prostate (15) and uterine (1) cancer16400.631.3%3.793.810.7 m (8–28 m)0
Karamanolis (2009, Greece)Prospective68.4 (45–86)Prostate cancer564025.4%2 (1–8)89.317.9 m (12–33 m)0
Latorre (2008, Spain)Prospective70.9 ± 7.38na3850–601.4–1.80.0%3.6 ± 2.786.828.5 ± 3.9 m0
Lenz (2011, Brazil)Prospective70.4 ± 11.1Prostate (8), cervical (5), and endometrial (2) cancer1540140%3.7 ± 1.793.312.5 m (2–30 m)0
Lpoez (2010, Mexico)Retrospective64 (25–80)Cervicouterine (5), endometrial (2), vaginal (2), prostate (9), and colorectal (1) cancer1940–501–1.55.3%2 (1–7)94.729 m (1–93 m)0
Onoyama (2011, Japan)Prospective74 ± 5.5Prostate cancer2430–4010.0%(1–7)10023.5 m (1–53 m)0
Rolachon (2000, France)Prospective70.3 ± 10Prostate (11) and endometrial (1) cancer1250125.0%2.8 ± 0.891.76 m0
Rotondano (2003, Italy)Prospective69.2 (22–81)Endometrial (13), cervical (6), and prostate (5) cancer24400.8–1.225.0%69, 2.5 (1–6)91.741 m (24–60 m)0
Sait (2013, Turkey)Retrospective61Prostate (6), rectum (2), cervix (12), and endometrium (1) cancer2150 (40–60)1.5 (1.2–2)23.8%3 (1–11)85.734.6 m0
Samy (2012, Egypt)Prospectivenana2340–500.8–1.00.0%na73.937 m (6–84 m)0
Sarah (2001, France)Prospective73 ± 3Prostate (9), uterine (1), and rectal (1) cancer11500.8–263.6%3.2 ± 0.410019 ± 2 m0
Sato (2011, Japan)Prospective72 (35–83)Prostate (46) and cervical (19) cancer65401.218.5%2 (1–5)93.834.6 m (3.6–121.1 m)0
Sebastian (2004, Ireland)Prospective69 (53–77)Prostate (23) and bladder (2) cancer2530 (25–50)1.50.0%1 (1–4)8414 m0
Silva (1999, Portugal)Prospective65 (42–77)Cervical (17), endometrial (7), and prostate (4) cancer28501.510.8%2.9 (1–8)96.410 m (1–15 m)0
Smith (2001, USA)ProspectivenaProstate cancer740–451.60.0%1–371.44–13 m0
Swan (2010, Australia)Prospective72.1 (51–87)Prostate (45), uterine (2), cervical (2), and vaginal (1) cancer50501.4–2.036.0%1.36 (1–3)9820.6 m (5–48 m)1
Takemoto (2012, Japan)ProspectivenaProstate cancer1230–4010.0%(1–3)83.335 m (12–69 m)0
Tam (2000, Australia)RetrospectivenaProstate (14) and cervical (1) cancer1560213.3%2 (1–4)10024 m (8–35 m)0
Tjandra (2001, Australia)Prospective73 (62–78)Prostate (10) and cervix (2) cancer12401.50.0%na5011 m (4–17 m)0
Venkatesh (2002, USA)Prospective64–83na4040–601.50.0%na97.53–30 m0
Villavicencio (2002, USA)Prospective72.6 (58–86)Prostate (15), endometrial (4), sacral chondroma (1), and cervical (1) cancer2145–501.2–219.0%1.7 (1–4)10010.5 m (1–29 m)0
Yeoh (2013, Australia)Prospective73 (49–87)Prostate cancer1760–8020.0%294.1110 m (29–170 m)0
Zinicola (2003, Italy)Retrospective68 (30–80)Prostate (8), cervical (4), and bladder (2) cancer146527.1%2.0 (1–4)83.319 m (5–41 m)2