Significance of Preoperative Systemic Immune Score for Stage I Gastric Cancer Patients

Table 3

Univariate and multivariate Cox proportional analysis for survival.

Parameter	Categories	Univariate analysis		Multivariate analysis
		HR (95% CI)		HR (95% CI)
Age	>65 versus <65	1.459 (0.974–2.186)	0.067
Gender	Male versus female	1.408 (0.853–2.327)	0.181
Tumor location	Upper versus other	1.254 (0.779–2.019)	0.351
Tumor size	≥30 mm versus <30 mm	1.555 (1.041–2.324)	0.031	1.302 (0.731–1.816)	0.452
Lymphovascular invasion	Yes versus no	2.660 (1.509–4.689)	0.001	2.314 (1.419–4.417)	0.010
Tumor differentiation	Undifferentiated versus differentiated	1.392 (0.933–2.077)	0.105
Extent of lymph node dissection	D1+/D1 versus D2	1.158 (0.643–1.391)	0.211
AJCC TNM stage	IB versus IA	10.183 (5.765–17.987)	<0.001	8.098 (5.201–13.145)	<0.001
CEA level	Above normal versus normal	2.433 (1.440–4.110)	0.001	1.488 (0.873–2.426)	0.319
CA 19–9 level	Above normal versus normal	1.363 (0.789–2.356)	0.267
Adjuvant chemotherapy	No versus yes	1.557 (0.784–3.092)	0.206
dNLR	≥2 versus <2	4.357 (2.910–6.524)	<0.001	2.464 (1.301–4.312)	0.004
Pretreatment hypoalbuminemia	Yes versus no	2.181 (1.404–3.387)	0.001	2.102 (1.254–3.576)	0.028
SIS classification	2 versus ≤1	4.955 (3.175–7.733)	<0.001	3.023 (1.977–6.501)	0.002

CA: carbohydrate antigen; CEA: carcinoembryonic antigen; CI: confidence interval; HR: hazard ratio.