Research Article

Comprehensive Complication Index Predicts Cancer-Specific Survival of Patients with Postoperative Complications after Curative Resection of Gastric Cancer

Table 3

Univariate and multivariate analyses for disease-specific survival in patients after curative resection of gastric cancer.

Univariate analysisMultivariate analysis
HR (95% CI)HR (95% CI)

Age (for 10-year increase)1.125 (1.076–1.176)<0.0011.123 (1.073–1.175)<0.001
Male sex (vs. female sex)0.979 (0.878–1.091)0.699
Charlson index ≥ 3 (vs. 0–2)1.126 (0.758–1.670)0.557
ASA classification ≥ 3 (vs. 1–2)1.212 (0.997–1.473)0.054
Neoadjuvant chemotherapy (vs. no)2.088 (1.557–2.799)<0.0011.927 (1.436–2.587)<0.001
Tumor diameter (for 10 mm increase)1.237 (1.217–1.258)<0.0011.104 (1.082–1.126)<0.001
Tumor stage II (vs. stage I)3.301 (2.485–4.385)<0.0012.765 (2.076–3.683)<0.001
Tumor stage III (vs. stage I)12.394 (9.703–15.831)<0.0018.759 (6.778–11.318)<0.001
Open gastrectomy (vs. LG)1.401 (1.273–1.543)<0.001
Total gastrectomy (vs. distal gastrectomy)1.789 (1.619–1.978)<0.001
Proximal gastrectomy (vs. distal gastrectomy)1.195 (0.857–1.667)0.293
Operative time (for 30-minute increase)1.109 (1.087–1.133)<0.001
Blood loss (for 50 mL increase)1.069 (1.052–1.085)<0.001
Adjuvant chemotherapy (vs. no)1.149 (1.047–1.261)0.0040.872 (0.791–0.962)0.002
Surgical period 2006–2014 (vs. 1996–2005)0.988 (0.894–1.092)0.817
Postoperative complication (vs. no)1.347 (1.189–1.526)<0.0011.194 (1.051–1.357)0.006