Evaluating IL-21 as a Potential Therapeutic Target in Crohn’s Disease

Figure 14

IL-21 expression and anti-IL-21 mAb treatment in piroxicam-accelerated colitis. Black circles PAC mice, black diamonds IL-10 k.o. mice, and black triangles C57BL6/j mice. Frequency of CD4⁺IL-21⁺-positive T cells in mesLN (a). Open circles anti-IL-21 25 mg/kg and black squares mIgG1 25 mg/kg. MPO levels in colonic biopsies at day 18 (b). Delta weight loss over time (days) (c). Serum haptoglobin levels on day 11 (d). Colon weight : length ratio (e). Endoscopic score encompassing (thickening of the colon, changes of vascular pattern, visible fibrin, granularity of mucosal surface, and stool consistency) on day 12 (f).

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