Table of Contents Author Guidelines Submit a Manuscript
Gastroenterology Research and Practice
Volume 2018, Article ID 7149565, 8 pages
https://doi.org/10.1155/2018/7149565
Research Article

Antitumor Activity of Intratumoral Ethanol Injection in an Orthotopic Pancreatic Cancer Cell Mouse Xenograft Model

1Department of Oncology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University, Shanghai, China
2Department of Gastroenterology, Changhai Hospital, The Second Military Medical University, Shanghai, China

Correspondence should be addressed to Bin Jiang; ten.haey@gnaij_nib

Received 5 September 2017; Revised 16 January 2018; Accepted 22 January 2018; Published 21 February 2018

Academic Editor: Niccola Funel

Copyright © 2018 Wen-Ying Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. Jemal, F. Bray, M. M. Center, J. Ferlay, E. Ward, and D. Forman, “Global cancer statistics,” CA: A Cancer Journal for Clinicians, vol. 61, no. 2, pp. 69–90, 2011. View at Publisher · View at Google Scholar · View at Scopus
  2. A. Stathis and M. J. Moore, “Advanced pancreatic carcinoma: current treatment and future challenges,” Nature Reviews Clinical Oncology, vol. 7, no. 3, pp. 163–172, 2010. View at Publisher · View at Google Scholar · View at Scopus
  3. K. Pliarchopoulou and D. Pectasides, “Pancreatic cancer: current and future treatment strategies,” Cancer Treatment Reviews, vol. 35, no. 5, pp. 431–436, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. A. Wiechowska-Kozłowska, K. Boer, M. Wójcicki, and P. Milkiewicz, “The efficacy and safety of endoscopic ultrasound-guided celiac plexus neurolysis for treatment of pain in patients with pancreatic cancer,” Gastroenterology Research and Practice, vol. 2012, Article ID 503098, 5 pages, 2012. View at Publisher · View at Google Scholar · View at Scopus
  5. Z. Jin, Y. Du, Z. Li, Y. Jiang, J. Chen, and Y. Liu, “Endoscopic ultrasonography-guided interstitial implantation of iodine 125-seeds combined with chemotherapy in the treatment of unresectable pancreatic carcinoma: a prospective pilot study,” Endoscopy, vol. 40, no. 4, pp. 314–320, 2008. View at Publisher · View at Google Scholar · View at Scopus
  6. J. R. Hecht, R. Bedford, J. L. Abbruzzese et al., “A phase I/II trial of intratumoral endoscopic ultrasound injection of ONYX-015 with intravenous gemcitabine in unresectable pancreatic carcinoma,” Clinical Cancer Research, vol. 9, no. 2, pp. 555–561, 2003. View at Google Scholar
  7. W. J. Yoon and W. R. Brugge, “Endoscopic ultrasonography-guided tumor ablation,” Gastrointestinal Endoscopy Clinics of North America, vol. 22, no. 2, pp. 359–369, 2012. View at Publisher · View at Google Scholar · View at Scopus
  8. W. J. Bean, “Renal cysts: treatment with alcohol,” Radiology, vol. 138, no. 2, pp. 329–331, 1981. View at Publisher · View at Google Scholar
  9. S. Omerovic and E. Zerem, “Alcohol sclerotherapy in the treatment of symptomatic simple renal cysts,” Bosnian Journal of Basic Medical Sciences, vol. 8, no. 4, pp. 337–340, 2008. View at Publisher · View at Google Scholar
  10. T. B. Larssen, D. K. Jensen, A. Viste, and A. Horn, “Single-session alcohol sclerotherapy in symptomatic benign hepatic cysts,” Acta Radiologica, vol. 40, no. 6, pp. 636–638, 1999. View at Publisher · View at Google Scholar
  11. T. Livraghi, L. Bolondi, S. Lazzaroni et al., “Percutaneous etharrol injection in the treatment of hepatocellular carcinoma in cirrhosis. A study on 207 patients,” Cancer, vol. 69, no. 4, pp. 925–929, 1992. View at Publisher · View at Google Scholar
  12. Y.-Y. Xiao, J.-L. Tian, J.-K. Li, L. Yang, and J.-S. Zhang, “CT-guided percutaneous chemical ablation of adrenal neoplasms,” American Journal of Roentgenology, vol. 190, no. 1, pp. 105–110, 2008. View at Publisher · View at Google Scholar · View at Scopus
  13. H. Aslanian, R. R. Salem, C. Marginean, M. Robert, J. H. Lee, and M. Topazian, “EUS-guided ethanol injection of normal porcine pancreas: a pilot study,” Gastrointestinal Endoscopy, vol. 62, no. 5, pp. 723–727, 2005. View at Publisher · View at Google Scholar · View at Scopus
  14. K. Matthes, M. Mino-Kenudson, D. V. Sahani, N. Holalkere, and W. R. Brugge, “Concentration-dependent ablation of pancreatic tissue by EUS-guided ethanol injection,” Gastrointestinal Endoscopy, vol. 65, no. 2, pp. 272–277, 2007. View at Publisher · View at Google Scholar · View at Scopus
  15. K. Matthes, M. Mino-Kenudson, D. V. Sahani et al., “EUS-guided injection of paclitaxel (OncoGel) provides therapeutic drug concentrations in the porcine pancreas (with video),” Gastrointestinal Endoscopy, vol. 65, no. 3, pp. 448–453, 2007. View at Publisher · View at Google Scholar · View at Scopus
  16. S. I. Gan, C. C. Thompson, G. Y. Lauwers, B. C. Bounds, and W. R. Brugge, “Ethanol lavage of pancreatic cystic lesions: initial pilot study,” Gastrointestinal Endoscopy, vol. 61, no. 6, pp. 746–752, 2005. View at Publisher · View at Google Scholar · View at Scopus
  17. H.-C. Oh, D. W. Seo, T. Y. Lee et al., “New treatment for cystic tumors of the pancreas: EUS-guided ethanol lavage with paclitaxel injection,” Gastrointestinal Endoscopy, vol. 67, no. 4, pp. 636–642, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. H.-C. Oh, D. W. Seo, T. J. Song et al., “Endoscopic ultrasonography-guided ethanol lavage with paclitaxel injection treats patients with pancreatic cysts,” Gastroenterology, vol. 140, no. 1, pp. 172–179, 2011. View at Publisher · View at Google Scholar · View at Scopus
  19. J. DeWitt, K. McGreevy, C. M. Schmidt, and W. R. Brugge, “EUS-guided ethanol versus saline solution lavage for pancreatic cysts: a randomized, double-blind study,” Gastrointestinal Endoscopy, vol. 70, no. 4, pp. 710–723, 2009. View at Publisher · View at Google Scholar · View at Scopus
  20. C. J. DiMaio, J. M. DeWitt, and W. R. Brugge, “Ablation of pancreatic cystic lesions: the use of multiple endoscopic ultrasound-guided ethanol lavage sessions,” Pancreas, vol. 40, no. 5, pp. 664–668, 2011. View at Publisher · View at Google Scholar · View at Scopus
  21. P. H. Deprez, A. Claessens, I. Borbath, J. F. Gigot, and D. Maiter, “Successful endoscopic ultrasound-guided ethanol ablation of a sporadic insulinoma,” Acta Gastroenterologica Belgica, vol. 71, pp. 333–337, 2008. View at Google Scholar
  22. N. Muscatiello, A. Salcuni, L. Macarini et al., “Treatment of a pancreatic endocrine tumor by ethanol injection guided by endoscopic ultrasound,” Endoscopy, vol. 40, pp. E258–E259, 2008. View at Publisher · View at Google Scholar
  23. F. Vleggaar, E. bij de Vaate, G. Valk, R. Leguit, and P. Siersema, “Endoscopic ultrasound-guided ethanol ablation of a symptomatic sporadic insulinoma,” Endoscopy, vol. 43, pp. E328–E329, 2011. View at Publisher · View at Google Scholar · View at Scopus
  24. L.-W. Lin, X.-Y. Lin, Y.-M. He et al., “Experimental and clinical assessment of percutaneous hepatic quantified ethanol injection in treatment of hepatic carcinoma,” World Journal of Gastroenterology, vol. 10, no. 21, pp. 3112–3117, 2004. View at Publisher · View at Google Scholar
  25. J. L. Ware and E. R. DeLong, “Influence of tumour size on human prostate tumour metastasis in athymic nude mice,” British Journal of Cancer, vol. 51, no. 3, pp. 419–423, 1985. View at Publisher · View at Google Scholar · View at Scopus
  26. J. Medioni, P. Leuraud, J. Y. Delattre, M.-F. Poupon, and J.-L. Golmard, “New criteria for analyzing the statistical relationships between biological parameters and therapeutic responses of xenografted tumor models,” Contemporary Clinical Trials, vol. 33, no. 1, pp. 178–183, 2012. View at Publisher · View at Google Scholar · View at Scopus
  27. K. Matsumoto, K. Yamao, K. Okubo et al., “Endoscopic ultrasound-guided ethanol injection in the pancreas in a porcine model: a preliminary study,” Journal of Gastroenterology and Hepatology, vol. 23, pp. e1–e6, 2008. View at Publisher · View at Google Scholar · View at Scopus
  28. C. Jürgensen, D. Schuppan, F. Neser, J. Ernstberger, U. Junghans, and U. Stölzel, “EUS-guided alcohol ablation of an insulinoma,” Gastrointestinal Endoscopy, vol. 63, no. 7, pp. 1059–1062, 2006. View at Publisher · View at Google Scholar · View at Scopus
  29. N. Muscatiello, M. Nacchiero, N. Della Valle et al., “Treatment of a pancreatic endocrine tumor by ethanol injection (PEI) guided by endoscopic ultrasound,” Endoscopy, vol. 40, article E83, 2008. View at Publisher · View at Google Scholar · View at Scopus
  30. M. J. Levy, G. B. Thompson, M. D. Topazian, M. R. Callstrom, C. S. Grant, and A. Vella, “US-guided ethanol ablation of insulinomas: a new treatment option,” Gastrointestinal Endoscopy, vol. 75, no. 1, pp. 200–206, 2012. View at Publisher · View at Google Scholar · View at Scopus
  31. K. Ohara, M. Kohno, and T. Horibe, “Local drug delivery to a human pancreatic tumor via a newly designed multiple injectable needle,” Molecular and Clinical Oncology, vol. 1, no. 2, pp. 231–234, 2013. View at Publisher · View at Google Scholar