Prognostic Value of Combination of Pretreatment Red Cell Distribution Width and Neutrophil-to-Lymphocyte Ratio in Patients with Gastric Cancer
Table 3
Cox proportional hazard regression analysis of patients’ overall survival.
Variables
Univariable
Multivariable
HR (95% CI)
HR (95% CI)
Age (≤54/>54)
1.698 (0.860–3.354)
0.127
Gender (F/M)
0.551 (0.282–1.075)
0.080
Tumor location (pyloric/nonpyloric antrum)
1.130 (0.580–2.204)
0.719
HER-2 (positive/negative)
1.818 (0.698–4.736)
0.221
RDW (≤13.4%/>13.4%)
3.497 (1.713–7.140)
0.001
WBC (≤5.69/>5.69 g/L)
2.165 (1.084–4.324)
0.029
1.323 (0.584–2.997)
0.502
MO (≤0.42/>0.42 g/L)
2.125 (1.067–4.232)
0.032
1.205 (0.521–2.790)
0.663
NLR (≤2.755/>2.755)
6.482 (3.131–13.418)
<0.001
CA125 (≤26.6/>26.6 U/mL)
2.241 (1.128–4.453)
0.021
1.858 (0.924–3.734)
0.082
CA199 (≤11.9/>11.9 U/mL)
1.479 (0.761–2.872)
0.248
CEA (≤2.4/>2.4 μg/L)
1.513 (0.773–2.961)
0.227
RDW + NLR
3.252 (1.289–8.203)
<0.001
3.197 (1.248–8.191)
<0.001
HR: hazard ratio; CI: confidence interval; RDW + NLR: combination of red blood cell distribution width and neutrophil-to-lymphocyte ratio. less than 0.05 is statistically significant. Univariate and multivariate analysis performed using Cox proportional hazards models. Multivariate analyses using the 5 significant variables (age, WBC, MO, CA125, and RDW + NLR, except RDW and NLR) above were performed. Significant factors in univariate and multivariate analysis are indicated in bold.
