Prognostic Value of Combination of Pretreatment Red Cell Distribution Width and Neutrophil-to-Lymphocyte Ratio in Patients with Gastric Cancer

Table 4

Cox proportional hazard regression analysis of patients’ progression-free survival.

Variables	Univariable		Multivariable
	HR (95% CI)		HR (95% CI)
Age (≤54/>54)	1.244 (0.709–2.184)	0.446
Gender (F/M)	0.854 (0.486–1.502)	0.585
Tumor location (pyloric/nonpyloric antrum)	1.17 (0.667–2.053)	0.584
HER-2 (positive/negative)	1.315 (0.614–2.816)	0.481
RDW (≤13.4%/>13.4%)	1.672 (0.943–2.964)	0.078
WBC (≤5.69/>5.69 g/L)	2.175 (1.227–3.856)	0.008	1.600 (0.781–3.277)	0.199
MO (≤0.42/>0.42 g/L)	1.870 (1.059–3.302)	0.031	0.987 (0.475–2.048)	0.971
NLR (≤2.755/>2.755)	4.187 (2.328–7.529)	<0.001
CA125 (≤26.6/>26.6 U/mL)	1.897 (1.077–3.343)	0.027	1.645 (0.918–2.945)	0.094
CA199 (≤11.9/>11.9 U/mL)	1.288 (0.733–2.264)	0.379
CEA (≤2.4/>2.4 μg/L)	1.609 (0.916–2.827)	0.098
RDW + NLR	1.923 (0.941–3.927)	<0.001	2.016 (0.982–4.136)	<0.001

HR: hazard ratio; CI: confidence interval; RDW: red cell distribution width; MO: monocyte; NLR: neutrophil-to-lymphocyte ratio; RDW + NLR: combination of red blood cell distribution width and neutrophil-to-lymphocyte ratio. less than 0.05 is statistically significant. Univariate and multivariate analysis performed using Cox proportional hazards models. Multivariate analyses using the 4 significant variables (WBC, MO, CA125, and RDW + NLR, except NLR) above were performed. Significant factors in univariate and multivariate analysis are indicated in bold.