Activation of Signal Transduction and Activator of Transcription 3 Signaling Contributes to Helicobacter-Associated Gastric Epithelial Proliferation and Inflammation

Figure 3

Cell proliferation rate in Stat3^Δgec mice. (a) Immunohistochemistry for Ki67 in WT and Stat3^Δgec mice. Uninfected (magnification ×200, scale bar 50 μm) (top) and infected mice at 18 months (magnification ×200, scale bar 50 μm) (bottom). (b) Proliferation of gastric epithelial cells as determined by Ki67 staining at 18 months postinfection with H. felis (). Uninfected mice were used as controls ( glands each). (c) CyclinD1 mRNA levels in the stomachs of Stat3^Δgec and WT mice at 18 months postinfection with H. felis ().

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