Mesenchymal Stem Cell Transplantation for Liver Cell Failure: A New Direction and Option

Table 1

Demographic and clinical features at enrollment in clinical trials.

Source	Year	Country	Number of enrolled patients	Age (year)	Disease	Causes of disease	Type of cells	Route of administration	Follow-up (month)	Assessments
Pan et al.	2008	China	10	18–27	LF	NA	BMSC	Hepatic/splenic artery	3	ALT, AST, PT, TBIL, DBIL, ALB, fibrinogen
Khan et al.	2008	India	4	NA	CLF	HBV:1, HCV:3	BMMSC	Hepatic artery	NA	ALB, BILALT, Child score, MELD
Peng et al.	2011	China	BMSC:53, control:105	BMSC: 42.19 ± 10.8; control: 42.22 ± 11.37	CLF	HBV	BMMSC	Hepatic artery	48	ALT, TBIL, PT, ALB, MELD
Amer et al.	2011	Egypt	BMSC: 20, control: 20	BMSC: 50.5 ± 4.1, control: 55 ± 3.6	CLF	HCV	BMHC	NA	6	Child score, MELD
Shi et al.	2012	China	UCMSC: 24, control: 19	UCMSC: 40, control: 45	ACLF	HBV	UCMSC	Cubital vein of the arm	18	ALT, TBIL, ALB, CHE, PTA, MELD
Park et al.	2013	Korea	5	44 ± 7.07	LF	HBV: 2, HCV: 2, other 1	BMMNC	Hepatic artery	12	ALT, Cr, INR, CT, Child scores, QoL
Wan et al.	2013	China	ACLF: 30, control: 20	ACLF: 43, control: 39	ACLF	HBV	HSC	NA	NA	ALT, TIBL, Cr, IL-6, MMP-2/9, Ishak score, Child class, MELD
Li et al.	2016	China	UCMSC + PE: 11, PE: 34	UCMSC + PE: 51.1 ± 11.2, PE: 50.0 ± 10.9	ACLF	HBV	UCMSC	Hepatic artery	24	ALT, AST, DBIL, TBIL, Cr, DBIL, PT, INR, AFP, MELD, USG, CT
Lin et al.	2017	China	BMSC: 56, control: 54	BMMSC: 40.04 ± 9.94, control: 42.78 ± 8.40	ACLF	HBV	BMMSC	Peripheral veins	6	ALB, ALT, TBIL, INR, CT, MRI, US, Cr, MELD

Data are expressed as mean ± standard deviation. NA: not available; ACLF: acute-on-chronic liver failure; UCMSC: umbilical cord-derived mesenchymal stem cell; BMSC: bone marrow-derived mesenchymal stromal cell; HSC: hematopoietic stem cell; ALB: albumin; ALT: alanine aminotransferase; AST: aspartate transaminase; TBIL: total bilirubin; DBIL: direct bilirubin; PT: prothrombin time; INR: international normalized ratio; Cr: creatinine; MELD: model for end-stage liver disease score; QoL: quality of life; CT: computed tomography scan: MRI: magnetic resonance imaging; US: ultrasonography.