Research Article

Diclofenac Sodium Treatment Ameliorates Extrapancreatic Organ Injuries in a Murine Model of Acute Pancreatitis Induced by Caerulein

Table 1

Histopathological results obtained from the kidney tissue according to groups.

Group 1 ()Group 2 ()Group 3 ()Group 4 ()Group 5 ()Group 6 ()Group 7 () value

Congestion0 (0–1)2 (1–2.5)a0 (0–1)b0.5 (0–1)b1 (1–2)a,c,d1 (1–2)a,c,d1.5 (1–2)a,c,d<0.001
Edema0 (0–1)1 (1–2.5)a0 (0–0.25)b0 (0–0)b1 (1–2)a,c,d1 (1–2)a,c,d1 (1–2)a,c,d<0.001
Tubular injury0 (0–0)1 (1–2)a0 (0–0.25)b0 (0–1)b1 (1–2)a,c,d1 (1–2)a,c,d1 (1–2)a,c,d<0.001
Parenchymal inflammation0 (0–0)0 (0–0)0 (0–0)0 (0–0)0 (0–0)0 (0–0)0 (0–0)0.253
Perirenal fat tissue inflammation0 (0–0)2 (1.5–3)a0 (0–0)b0 (0–0)b2 (1–2)a,c,d1.5 (1–2)a,c,d1 (1–2)a,c,d<0.001
Tubular stasis0 (0–0)1 (0–1.5)a0 (0–0)b0 (0–0)b1 (0–1)a,c,d0 (0–1)0 (0–1)0.048

Data were shown as median (25th–75th) percentiles, the Kruskal–Wallis test. aThe difference between the considered group and group 1 was found as statistically significant (). bThe difference between the considered group and group 2 was found as statistically significant (). cThe difference between the considered group and group 3 was found as statistically significant (). dThe difference between the considered group and group 4 was found as statistically significant ().