Diclofenac Sodium Treatment Ameliorates Extrapancreatic Organ Injuries in a Murine Model of Acute Pancreatitis Induced by Caerulein

Table 4

Histopathological results obtained from the liver tissue according to groups.

	Group 1 ()	Group 2 ()	Group 3 ()	Group 4 ()	Group 5 ()	Group 6 ()	Group 7 ()	value^†
Congestion	0 (0–1)	1 (1–1.5)^a	0 (0–0.25)^b	0 (0–1)^b	1 (0–1)^b	1 (0–1)^b	1 (0–1)^b	0.029
Hydropic degeneration	0 (0–1)	2 (1–2)^a	0 (0–0.25)^b	0 (0–1)^b	1 (0–1.5)^b,c	1 (0.75–1.25)^a,c,d	1 (0–1)^b	0.002
Focal necrosis	0 (0–0)	0 (0–1)	0 (0–0.25)	0 (0–0)	0 (0–0.5)	0 (0–0.25)	0 (0–0)	0.640
Portal inflammation	0 (0–0)	0 (0–1)	0 (0–0)	0 (0–0)	0 (0–0.5)	0 (0–1)	0 (0–0)	0.259
Portal fibrosis	0 (0–0)	0 (0–0)	0 (0–0)	0 (0–0)	0 (0–0)	0 (0–0)	0 (0–0)	>0.999

Data were shown as median (25th–75th) percentiles, the Kruskal–Wallis test. ^aThe difference between the considered group and group 1 was found as statistically significant (). ^bThe difference between the considered group and group 2 was found as statistically significant (). ^cThe difference between the considered group and group 3 was found as statistically significant (). ^dThe difference between the considered group and group 4 was found as statistically significant ().