Tanshinone IIA Sodium Sulfonate Attenuates LPS-Induced Intestinal Injury in Mice

Figure 6

Autophagosome formation in each group. Representative transmission electron microscope images of each group. (a) A: the control group showed the normal jejunum electron microscopy images; B, C, D: electron microscopy images in jejunum endothelium of LPS-induced mice; E, F, G: the electron microscopy images changed in the jejunum epithelial cells when treated with TSS and LPS. (b) Random cells were chosen to determine the number of autophagosomes/cell for each treatment condition. The black arrowheads indicate membrane-bound vacuoles that are characteristic of autophagosomes. LPS: lipopolysaccharide; TSS: tanshinone IIA sodium sulfonate. Blank column indicates control group; dot column indicates LPS treatment at all observed time points; diagonal column indicates TSS pretreatment at all observed time points; in each group. Each bar presents the mean ± SEM. versus LPS group.

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