Colorectal Serrated Neoplasia: An Institutional 12-Year Review Highlights the Impact of a Screening Programme
Table 6
Histological features of hyperplastic polyps with prolapse, sessile serrated lesions/polyps, and traditional serrated adenomas [1, 11, 18].
HYP with prolapse effect
HYP: (i) Simple, elongated crypts (ii) Serrated structure in the upper half of the crypts (iii) Some proliferation in the basal (non-serrated) part of the crypts Prolapse: (i) Thickening of the muscularis mucosae (ii) Upward extension from the hypertrophic & splayed muscularis mucosae (iii) Fibromuscular obliteration of the lamina propria, with dilated crypts
SSL/P
(i) At least one unequivocal architecturally distorted, dilated, &/or horizontally branched crypt (“L,” “boot,” or “anchor”-shaped crypt) (ii) Inverted maturation (excessive/hyper-serration in the basal half of crypts)
TSA
(i) Striking granular eosinophilic cytoplasm (ii) Luminal serrations (iii) Ectopic crypt foci (iv) Elongated, pencillate nuclei with evenly dispersed coarse chromatin & small inconspicuous nucleoli
