Gastroenterology Research and Practice / 2019 / Article / Tab 6

Research Article

Colorectal Serrated Neoplasia: An Institutional 12-Year Review Highlights the Impact of a Screening Programme

Table 6

Histological features of hyperplastic polyps with prolapse, sessile serrated lesions/polyps, and traditional serrated adenomas [1, 11, 18].

HYP with prolapse effectHYP:
(i) Simple, elongated crypts
(ii) Serrated structure in the upper half of the crypts
(iii) Some proliferation in the basal (non-serrated) part of the crypts
Prolapse:
(i) Thickening of the muscularis mucosae
(ii) Upward extension from the hypertrophic & splayed muscularis mucosae
(iii) Fibromuscular obliteration of the lamina propria, with dilated crypts

SSL/P(i) At least one unequivocal architecturally distorted, dilated, &/or horizontally branched crypt (“L,” “boot,” or “anchor”-shaped crypt)
(ii) Inverted maturation (excessive/hyper-serration in the basal half of crypts)

TSA(i) Striking granular eosinophilic cytoplasm
(ii) Luminal serrations
(iii) Ectopic crypt foci
(iv) Elongated, pencillate nuclei with evenly dispersed coarse chromatin & small inconspicuous nucleoli

Abbreviations: HYP: hyperplastic polyp; SSL/P: sessile serrated lesion/polyp; TSA: traditional serrated adenoma.

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