Abnormal Expression of Fgf9 during the Development of the Anorectum in Rat Embryos with Anorectal Malformations

Figure 1

(a, b) On E13, normal embryos had typical cloacal morphology, and URS divided the cloaca into UGS and hindgut. Abundant Fgf9 immunopositive cells were present in the cloacal mesenchyme. (c, d) In ARM embryos, Fgf9-positive cells were rarely present in the mesenchyme. URS: urorectal septum; UGS: urogenital sinus; H: hindgut; CL: cloaca. Original magnification: ×100 (a, c); ×200 (b, d).

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