Review Article

Gene Polymorphisms and Susceptibility to Functional Dyspepsia: A Systematic Review and Meta-Analysis

Table 2

Meta-analyses of GNB3 825C>T, SCL6A4 5HTTLPR, and CCK-1R 779T>C polymorphisms and FD susceptibility.

GroupStudies ()Case-control ()Additive model

GNB3 825C>TOR (95% CI) value2 (%) value
Overall131390/30581.15 (0.99-1.34)0.0752.90.01
Not deviate HWE111223/26771.16 (1.04-1.29)0.0547.30.04
EPS8308/17871.34 (1.10-1.63)0.00346.60.07
HWE+6276/15941.44 (1.17-1.77)0.00146.80.09
PDS8328/17871.19 (0.99-1.43)0.0749.30.06
Not deviate HWE6261/15941.29 (1.03-1.62)0.0336.30.17
SCL6A4 5HTTLPROR (95% CI) value2 (%) value
Overall4326/12850.92 (0.75-1.12)0.4057.00.07
EPS3106/9490.73 (0.52-1.04)0.0825.20.26
PDS3121/9490.75 (0.54-1.04)0.0857.20.10
CCK-1R 779T>COR (95% CI) value2 (%) value
Overall4521/6770.86 (0.72-1.03)0.0940.90.17