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Gastroenterology Research and Practice
Volume 2019, Article ID 3903451, 6 pages
Research Article

Effects of Permissive Hypercapnia on Laparoscopic Surgery for Rectal Carcinoma

Department of Anesthesiology, Cangzhou Central Hospital, Cangzhou 061000, China

Correspondence should be addressed to Shiqiang Shan; moc.361@6471gnaiqihsnahs

Received 25 October 2018; Revised 14 January 2019; Accepted 25 August 2019; Published 7 October 2019

Academic Editor: Eiji Sakai

Copyright © 2019 Lei Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Permissive hypercapnia has been recommended during the treatment of chronic diseases; however, there are insufficient clinical data to investigate the feasibility of permissive hypercapnia in relatively long-term surgeries such as laparoscopic surgery for rectal carcinoma. This prospective study is aimed at investigating the efficacy and safety of permissive hypercapnia under different CO2 pneumoperitoneum pressures during the laparoscopic surgery for rectal carcinoma. Methods. A total of 90 patients undergoing laparoscopic surgery for rectal carcinoma were recruited from July 2016 to March 2017. They were randomly assigned to high hypercapnia group (), low hypercapnia group (), or control group (), whose PaCO2 levels were maintained at 56-65 mmHg, 46-55 mmHg, or 35-45 mmHg, respectively. The primary endpoint was peak pressure. Plateau pressure, dynamic compliance, arterial blood analysis, and hemodynamic measures were collected as secondary outcomes. Adverse events were monitored. Results. High hypercapnia group were reported to be associated with significantly lower peak pressure and plateau pressure, but higher dynamic compliance compared to low hypercapnia and control group (all ). Moreover, patients in the high hypercapnia group had higher postoperation oxygenation index values compared to those in the low hypercapnia and control group (all ). There is no significant difference in the pH, Spo2, MAP, heart rate, and adverse events among the three groups. Conclusion. Permissive hypercapnia with a PaCO2 level of 56-65 mmHg was able to improve respiratory function after laparoscopic surgery in rectal cancer patients.