Association of Ulcerative Colitis with FOXP3 Gene Polymorphisms and Its Colonic Expression in Chinese Patients
Table 3
Association of FOXP3 polymorphisms with the clinical features in female patients with ulcerative colitis (UC) [frequency (%)].
FOXP3
Severity of UC
Extent of UC
Mild and moderate ()
Severe ()
Distal colitis ()
Extensive colitis ()
rs3761548
CC
96 (62.0)
30 (39.0)
86 (52.4)
40 (58.8)
CA + AA
59 (38.0)
47 (61.0)a
78 (47.6)
28 (41.2)
C
230 (74.2)
95 (61.7)
231 (70.4)
94 (69.1)
A
80 (25.8)
59 (38.3)b
97 (29.6)
42 (30.9)
rs2232365
AA
62 (40.0)
10 (13.0)
46 (28.1)
26 (38.2)
AG + GG
93 (60.0)
67 (87.0)c
118 (71.9)
42 (61.8)
A
178 (57.4)
71 (46.1)
174 (53.1)
75 (55.1)
G
132 (42.6)
83 (53.9)d
154 (46.9)
61 (44.9)
rs2294021
CC
47 (30.3)
3 (3.9)
32 (19.5)
18 (26.5)
CT + TT
108 (69.7)
74 (96.1)e
132 (80.5)
50 (73.5)
C
145 (46.8)
48 (31.2)
136 (41.5)
57 (41.9)
T
165 (53.2)
106 (68.8)f
192 (58.5)
79 (58.1)
rs3761547
CC
12 (7.7)
4 (5.2)
11 (6.7)
5 (7.3)
CA + AA
143 (92.3)
73 (94.8)
153 (93.3)
63 (92.7)
C
60 (19.4)
30 (19.5)
63 (19.2)
27 (19.9)
A
250 (80.6)
124 (80.5)
265 (80.8)
109 (80.1)
All listed ORs, 95% CIs, and value were calculated for each SNP analyzed using logistic regression after adjusted for age, gender, and smoking. ,,95% CI 1.454-4.468. ,,95% CI 1.182-2.698. ,,95% CI 2.135-9.344. ,,95% CI 1.069-2.325. ,,95% CI 3.220-35.784. ,,95% CI 1.291-2.917.
