Contrast-Enhanced CT May Be a Diagnostic Alternative for Gastroesophageal Varices in Cirrhosis with and without Previous Endoscopic Variceal Therapy

Table 2

Diagnostic performance of alternative approaches.

Variables	Primary prophylaxis population			Acute bleeding population			Previous bleeding population			Secondary prophylaxis population
	No. pts	AUC (95% CI)	value	No. pts	AUC (95% CI)	value	No. pts	AUC (95% CI)	value	No. pts	AUC (95% CI)	value
EVs
APRI score	70	0.550; (0.426-0.669)	0.5207	38	0.876; (0.729-0.960)	<0.0001	67	0.523; (0.398-0.647)	0.8813	104	0.532; (0.432-0.630)	0.7526
AAR score	70	0.550; (0.426-0.669)	0.5142	38	0.714; (0.545-0.849)	0.4083	67	0.672; (0.547-0.782)	0.2117	104	0.513; (0.413-0.613)	0.8961
FIB4 score	70	0.632; (0.508-0.744)	0.0852	38	0.771; (0.607-0.892)	0.0314	67	0.538; (0.412-0.661)	0.8163	104	0.536; (0.436-0.635)	0.7489
King score	68	0.586; (0.460-0.704)	0.2556	38	0.838; (0.683-0.937)	0.0002	67	0.500; (0.375-0.625)	1.0000	102	0.525; (0.424-0.625)	0.8078
Lok score	68	0.654; (0.529-0.766)	0.0342	38	0.905; (0.765-0.976)	<0.0001	67	0.503; (0.378-0.627)	0.9863	102	0.593; (0.491-0.689)	0.4019
PSR	68	0.755; (0.636-0.852)	0.0001	37	0.882; (0.734-0.965)	<0.0001	60	0.664; (0.530-0.780)	0.2587	81	0.633; (0.519-0.738)	0.2900
Contrast-enhanced CT	70	0.680; (0.588-0.787)	0.0004	38	0.833; (0.677-0.934)	0.0455	67	0.833; (0.722-0.913)	0.0016	104	0.739; (0.644-0.821)	0.0042
EVNTs
APRI score	67	0.490; (0.366-0.615)	0.8912	38	0.513; (0.346-0.679)	0.8984	66	0.551; (0.424-0.674)	0.5592	104	0.564; (0.463-0.661)	0.2649
AAR score	67	0.475; (0.352-0.601)	0.7264	38	0.648; (0.477-0.796)	0.1905	66	0.547; (0.419-0.670)	0.5854	104	0.616; (0.516-0.710)	0.0344
FIB4 score	67	0.542; (0.416-0.665)	0.5567	38	0.549; (0.379-0.710)	0.6382	66	0.500; (0.374-0.626)	1.0000	104	0.502; (0.402-0.601)	0.9786
King score	65	0.516; (0.389-0.642)	0.8272	38	0.505; (0.338-0.671)	0.9608	66	0.571; (0.444-0.693)	0.4147	102	0.519; (0.418-0.619)	0.7456
Lok score	65	0.557; (0.428-0.680)	0.4315	38	0.582; (0.412-0.740)	0.4786	66	0.570; (0.442-0.691)	0.4231	102	0.546; (0.444-0.644)	0.4251
PSR	65	0.670; (0.542-0.782)	0.0126	37	0.738; (0.567-0.868)	0.0127	59	0.688; (0.554-0.802)	0.0185	81	0.595; (0.480-0.703)	0.1428
Contrast-enhanced CT	67	0.876; (0.772-0.944)	<0.0001	38	0.816; (0.658-0.923)	0.0001	66	0.873; (0.768-0.942)	<0.0001	103	0.673; (0.574-0.762)	0.0012
GVs
APRI score	69	0.541; (0.417-0.662)	0.5846	38	0.589; (0.418-0.745)	0.3527	67	0.588; (0.461-0.707)	0.2517	104	0.532; (0.432-0.631)	0.6022
AAR score	69	0.709; (0.587-0.812)	0.0009	38	0.611; (0.439-0.764)	0.2412	67	0.549; (0.423-0.671)	0.5593	104	0.565; (0.464-0.662)	0.2948
FIB4 score	69	0.636; (0.512-0.749)	0.0679	38	0.535; (0.366-0.698)	0.7206	67	0.621; (0.494-0.737)	0.1027	104	0.499; (0.399-0.599)	0.9867
King score	67	0.546; (0.420-0.669)	0.5393	38	0.554; (0.384-0.715)	0.5756	67	0.618; (0.491-0.734)	0.1236	104	0.508; (0.407-0.609)	0.8952
Lok score	67	0.672; (0.547-0.782)	0.0079	38	0.551; (0.382-0.713)	0.6018	67	0.499; (0.375-0.624)	0.9944	102	0.534; (0.432-0.633)	0.5642
PSR	67	0.664; (0.538-0.774)	0.0236	37	0.614; (0.440-0.769)	0.2334	60	0.603; (0.469-0.727)	0.2093	81	0.510; (0.396-0.623)	0.8834
Contrast-enhanced CT	68	0.721; (0.599-0.823)	0.0005	38	0.605; (0.434-0.760)	0.1797	67	0.671; (0.546-0.781)	0.0076	102	0.686; (0.586-0.774)	0.0001
GVNTs
APRI score	68	0.583; (0.457-0.702)	0.4108	38	0.559; (0.389-0.720)	0.5561	67	0.575; (0.448-0.695)	0.3073	104	0.612; (0.511-0.706)	0.1463
AAR score	68	0.648; (0.523-0.760)	0.0691	38	0.601; (0.430-0.756)	0.2862	67	0.637; (0.510-0.751)	0.0499	104	0.536; (0.436-0.635)	0.6585
FIB4 score	68	0.598; (0.472-0.715)	0.3457	38	0.478; (0.314-0.646)	0.8230	67	0.614; (0.487-0.731)	0.1072	104	0.646; (0.546-0.738)	0.0480
King score	66	0.558; (0.431-0.680)	0.5559	38	0.513; (0.346-0.678)	0.8954	67	0.616; (0.489-0.732)	0.1092	102	0.627; (0.525-0.721)	0.1144
Lok score	66	0.626; (0.498-0.742)	0.1504	38	0.536; (0.367-0.699)	0.7158	67	0.497; (0.372-0.622)	0.9661	102	0.524; (0.422-0.624)	0.7894
PSR	67	0.631; (0.505-0.746)	0.2201	37	0.615; (0.441-0.770)	0.2333	60	0.555; (0.421-0.684)	0.4711	81	0.579; (0.464-0.687)	0.4057
Contrast-enhanced CT	64	0.731; (0.605-0.834)	0.0316	35	0.639; (0.460-0.794)	0.1502	64	0.602; (0.472-0.723)	0.1628	100	0.661; (0.559-0.753)	0.0259

PSR was not available in patients with splenectomy. APRI: aspartate aminotransferase to platelet ratio index; AAR: aspartate aminotransferase to alanine aminotransferase ratio; FIB4: fibrosis 4 index; PSR: platelet count to spleen diameter ratio; CT: computed tomography; AUC: area under the curve; CI: confidence interval; EVs: esophageal varices; EVNTs: esophageal varices needing treatment; GVs: gastric varices; GVNTs: gastric varices needing treatment.