Laparoscopic versus Open Surgery in Lateral Lymph Node Dissection for Advanced Rectal Cancer: A Meta-Analysis
Table 3
Subgroup analysis between laparoscopic LLND and robotic-assisted laparoscopic LLND.
Outcomes of interest
Studies ()
L/RL ()
O ()
WMD/OR/HR (95% CI)
value
Subgroup difference
df
(%)
value
Operative time (min)
L vs O
6
231
332
88.03† (9.20-166.87)
0.03
1.06
1
5.8
0.30
RL vs O
1
85
88
45.00† (22.92-67.08)
<0.00001
Estimated blood loss (ml)
L vs O
6
231
332
-407.11† (-585.92 to -228.31)
<0.00001
3.83
1
73.9
0.05
RL vs O
1
85
88
-612.00† (-712.55 to -511.45)
<0.00001
Postoperative hospital stay (days)
L vs O
4
113
214
-6.27† (-10.43 to -2.11)
0.003
1.94
1
48.5
0.16
RL vs O
1
85
88
-3.00† (-4.98 to -1.02)
0.003
Lateral lymph node harvest ()
L vs O
4
192
230
-0.56† (-6.01 to 4.89)
0.84
0.21
1
0
0.65
RL vs O
2
163
166
0.82† (-1.37 to 3.00)
0.46
Lateral lymph node metastasis
L vs O
3
180
217
1.17 (0.69-1.97)
0.56
0.78
1
0
0.38
RL vs O
1
85
88
0.77 (0.35-1.66)
0.50
R0 resection status
L vs O
4
203
192
1.80 (0.89-3.67)
0.10
1.14
1
12.6
0.28
RL vs O
2
163
166
5.08 (0.88-29.40)
0.07
3-year overall survival
L vs O
3
191
179
1.30(0.46-3.66)
0.62
0.63
1
0
0.43
RL vs O
1
78
78
0.09(0.00-60.77)
0.47
3-year disease-free survival
L vs O
3
191
179
1.01(0.67-1.52)
0.97
0.12
1
0
0.73
RL vs O
1
78
78
0.85(0.37-1.98)
0.71
L = laparoscopic surgery; RL = robotic-assisted laparoscopic surgery; O = open surgery; VS = versus; WMD = weighted mean difference; OR = odds ratio; HR = hazard ratio; CI = confidence interval; df = degrees of freedom. HR; †WMD.
