Preoperative Serum Platelet-Lymphocyte Ratio as a Prognostic Factor in Cholangiocarcinoma Patients after Radical Resection: A Retrospective Analysis of 119 Patients

Table 4

Kaplan–Meier method and Cox proportional hazard regression analysis of patients’ progression-free survival.

Variable	Univariable		Multivariable
	HR (95% CI)	value	HR (95% CI)	value
Gender (female/male)	1.056 (0.683-1.633)	0.802
Age (years) (<60/≥60)	1.068 (0.693-1.646)	0.758
ECOG (<2/=2)	1.419 (0.680-2.965)	0.332
Tumor location (iCC/pCC/dCC)	0.406 (0.519-0.873)	0.004	0.566 (0.428-0.749)	<0.001
Lymphatic metastasis (no/yes)	1.641 (0.945-2.849)	0.066
Surgical margin (negative/positive)	1.979 (1.263-3.101)	0.002	1.567 (0.989-2.482)	0.056
Tumor size (mm) (≤40/>40)	1.692 (1.088-2.633)	0.015	0.935 (0.571-1.531)	0.790
Differentiation (poor/moderated/well)	0.330 (0.293-0.593)	<0.001	0.411 (0.287-0.587)	<0.001
Vascular invasion (no/yes)	1.151 (0.488-2.715)	0.741
Nerve invasion (no/yes)	0.854 (0.461-1.582)	0.605
PLR (<157.25/≥157.25)	1.979 (1.269-3.086)	0.002	1.930 (1.220-3.053)	0.005
CA199 (U/ml) (≤38/>38)	1.354 (0.833-2.199)	0.205
TBIL (μmol/L) (≤115/>115)	0.870 (0.565-1.340)	0.515

Abbreviations: PLR: platelet-lymphocyte ratio; ECOG: Eastern Cooperative Oncology Group; iCC: intrahepatic cholangiocarcinoma; pCC: perihilar cholangiocarcinoma; dCC: distal cholangiocarcinoma; CA199: carbohydrate antigen 19-9; TBIL: total bilirubin; HR: hazard ratio; CI: confidence; was considered significant.