Meta-Analysis of Antinuclear Antibodies in the Diagnosis of Antimitochondrial Antibody-Negative Primary Biliary Cholangitis
Table 2
Ethnicity subgroup analysis of ANAs in the diagnostic accuracy of ANAs.
Analyses
No. of studies
Pooled sensitivity (95% CI)
Pooled specificity (95% CI)
Pooled+LR (95% CI)
Pooled−LR (95% CI)
DOR (95% CI)
Total
11
0.27 (0.20, 0.35)
76.64
<0.01
0.98 (0.97, 0.99)
94.46
<0.01
17.1 (8.1, 36.4)
0.74 (0.67, 0.82)
23 (10, 53)
Asian
3
0.23 (0.10, 0.44)
64.68
0.01
0.97 (0.93, 0.99)
83.94
<0.01
6.9 (2.1, 23.2)
0.80 (0.63, 1.00)
9 (2, 35)
Caucasian
8
0.28 (0.21, 0.37)
79.01
<0.01
0.99 (0.97, 0.99)
95.90
<0.01
21.7 (8.6, 54.6)
0.72 (0.64, 0.82)
30 (11, 82)
Anti-gp210
7
0.23 (0.13, 0.37)
75.15
<0.01
0.99 (0.97, 1.00)
69.37
<0.01
21.9 (6.0, 80.4)
0.78 (0.67, 0.91)
28 (7, 111)
Anti-sp100
8
0.25 (0.13, 0.43)
81.37
<0.01
0.97 (0.93, 0.98)
87.88
<0.01
7.7 (2.3, 25.7)
0.77 (0.62, 0.96)
10 (2, 41)
Anti-gp210 in Asian
3
0.31 (0.16, 0.50)
26.80
0.26
0.96 (0.94, 0.98)
50.60
0.13
8.6 (3.6, 20.7)
0.70 (0.55, 0.89)
12 (4, 33)
Anti-gp210 in Caucasian
4
0.18 (0.09, 0.33)
81.03
<0.01
0.99 (0.98, 1.00)
24.55
0.26
32.4 (6.6, 157.9)
0.83 (0.71, 0.96)
39 (7, 213)
Anti-sp100 in Asian
3
0.20 (0.06, 0.44)
83.20
0.02
0.95 (0.92, 0.97)
95.50
<0.01
3.6 (0.01, 1491.4)
0.71 (0.14, 3.57)
5 (0, 1599)
Anti-sp100 in Caucasian
5
0.30 (0.16, 0.50)
82.90
<0.01
0.97 (0.94, 0.99)
77.72
<0.01
11.0 (3.1, 39.7)
0.72 (0.55, 0.93)
15 (3, 71)
The ethnicity subgroup analysis is shown in this table, including the subgroup, numbers of studies, pooled sensitivity, pooled specificity, pooled positive LR, pooled negative LR, and DOR. The subgroup meta-analysis was performed in Meta-DiSc. Other subgroup meta-analyses were performed in STATA. Abbreviations: LR: likelihood ratio; DOR: diagnostic odds ratio.
