Safety of Simultaneous Hepatectomy and Splenectomy in the Treatment of Hepatocellular Carcinoma Complicated with Hypersplenism: A Meta-analysis

Table 3

Egger’s publication bias test for effects of HS vs. HA in the treatment of patients with HCC and hypersplenism.

Outcomes	No. of trials	No. of patients	Coef. for bias	for bias	95% CI for bias
5-year DFS rate	4	858	0.817	0.614	-23.332, 18.983
5-year OS rate	4	858	2.483	0.788	-32.334, 37.300
Operation time	5	751	-0.705	0.867	-13.030, 11.620
Intraoperative blood loss	8	1228	1.276	0.206	-0.927, 3.479
Intraoperative blood transfusion	6	1132	0.827	0.001	0.548, 1.105
Postoperative complications	10	1360	2.688	0.264	-2.476, 7.853
Perioperative mortality	8	1002	-1.009	0.345	-3.419, 1.402
PLT count at POD 7	5	168	5.815	0.021	1.693, 9.937
T-Bil content at POD 7	5	170	-2.663	0.383	-10.968, 5.641

Abbreviations: DFS: disease-free survival; OS: overall survival; PLT: platelet; T-Bil: total bilirubin; POD: postoperative day; Coef.: coefficient; CI: confidence interval.